摘要
目的:比较七氟烷对顺式阿曲库铵和罗库溴铵肌松效应的影响。方法:择期手术患者240例,随机分为顺式阿曲库铵组(CIS120例)和罗库溴铵组(ROC120例)。两组患者再随机分为丙泊酚组(60例)和七氟烷组(60例),均静脉注射咪达唑仑、芬太尼和丙泊酚行麻醉诱导,丙泊酚组靶控输注丙泊酚维持麻醉,设定血浆靶控浓度2～6μg/mL,输注丙泊酚5min后静脉注射顺式阿曲库铵0.15mg/kg或罗库溴铵0.6mg/kg;七氟烷组在呼气末七氟烷浓度稳定于1MAC5min后静脉注射顺式阿曲库铵0.15mg/kg或罗库溴铵0.6mg/kg。结果:CIS两组,起效时间差异无统计学意义(P>0.05);七氟烷组完全肌松时间、维持时间与丙泊酚组比较均显著延长(P<0.01)。ROC两组,起效时间差异无统计学意义(P>0.05);七氟烷组完全肌松时间、维持时间与丙泊酚组比较均显著延长(P<0.01)。结论:七氟烷对顺式阿曲库铵及罗库溴铵的肌松均有增效作用。
Objective To compare the effects of sevoflurane on neuromuscular blockade induced by cisatracurium or rocureonium.Methods Two hundred and 40 patients for elective surgery were randomized to receive a single bolus dose of cisatracurium（0.15 mg/kg） or rocuronium（0.6 mg/kg）.Patients were randomly assigned to one of 2 groups（n=60 each）：propofol group（group P） and sevoflurane group（group S）.All patients were anesthetized with midazolam,propofol and fentany.After loss of consciousness laryngeal mask was inserted.Anesthesia was maintained with blood target-controlled infusion（TCI） of propofol in group P.Propofol was infused at the target concentration of 2～6 μg/ml.and after propofol infusion for 5 min,cisatracurium,0.15 mg/kg or rocuronium,0.6 mg/kg was given i.v..In group S,anesthesia was maintained with IMAC of sevoflurane.Cisatracurium,0.15 mg/ke or rocuronium,0.6 mg.kg was given i.v.when end-tidal concentration of sevoflurance was 1.71%.Neuromuscular function eas assessed by accelerogrphy.TOF stimulation of ulnar nerve was used.The onset time,recovery of first twitch（T1） and recovery of TOF 25% were recorded.Results In the cisatracurium group,the onset time was similar,while recovery of T1 and duration of action were longer in group S than in group P.In the rocuronium group,the onset time was similar,while recovery of T1 and duration of action were longer in group S than those of group P.Conclusion Sevofluranne can enhance the neuromuscular blockade of cisatracurium or rocuronium
出处
《中国中西医结合外科杂志》
CAS
2011年第2期165-167,共3页
Chinese Journal of Surgery of Integrated Traditional and Western Medicine
