ERK5基因-322G/T多态性与散发性结直肠癌易感性的关系

Association between ERK5 -322G/T polymorphism and genetic susceptibility to sporadic colorectal cancer

目的:探讨有丝分裂原活化蛋白激酶(MAPK)信号通路ERK5基因-322G/T(rs3866958)单核苷酸多态性与中国华南地区散发性结直肠癌(CRC)易感性的关系。方法:采用Taqman-MGB荧光探针法检测华南地区835例肠癌和908例正常对照的ERK5基因-322G/T单个核苷酸的多态性。结果:ERK5基因单核苷酸多态性位点-322G/T等位基因在结直肠癌患者和健康对照人群中分布差异无统计学意义(P>0.05),但在BMI≥24kg/m^2的肥胖人群中-322G/T的分布差异显著,与GG基因型相比,GT、TT基因型携带者的CRC发病风险下降42.4%(OR=0.576,95%CI 0.413-0.804,P<0.01)。结论:ERK5基因-322G/T单核苷酸多态性与结直肠癌发病无明显相关性,但可显著降低肥胖患者发病风险;-322T基因型是中国南方人群散发性结直肠癌肥胖患者的独立保护因素。

AIM：To investigate the correlation between extracellular signal-regulated kinase 5（ERK5）- 322G/T polymorphism（rs3866958）and the susceptibility to sporadic colorectal cancer（CRC）in southern Chinese population. METHODS：ERK5-322G/T genotypes were determined by Taqman-MGB probes in 835 CRC cases and 908 healthy controls.RESULTS：No significance of ERK5-322G/T genotype distribution between CRC patients and controls was observed,but-322G/T decreased the susceptibility to CRC in fat people whose BMI was≥24 kg/m^2.Compared to GG genotypes,the carriers with GT and TT genotypes had a significant decrease in the risk of CRC（OR=0.576,95%CI 0.413-0.804,P〈0.01）.CONCLUSION：ERK5-322G/T polymorphism（rs3866958）has no significant relevance with sporadic CRC susceptibility,but decrease the risk of CRC in people with fatness.The T variant genotype is an independent protective factor against sporadic CRC of overweight patients in southern Chinese population.