SonoVue与Sonazoid高频条件下对兔肝显像效果的对比分析

Comparison of the imaging effects of SonoVue and Sonazoid at high frequency in rabbit-liver ultrasonography

目的探讨两种超声造影剂不同剂量和机械指数（MI）条件下的显像效果。方法分别对8只新西兰大白兔多次团注超声造影剂SonoVue（0．06ml／kg、0．12ml／kg）及Sonazoid（0．045ml／kg、0．09ml／kg），SonoVue组每个剂量水平分别设置7个MI值（O．10～0．55），Sonazoid组每个剂量水平分别设置5个MI值（O．19～0．98）。应用视频密度分析软件对显像过程做定量分析，并比较其峰值强度（PI）。结果在相同发射频率（7MHz）条件下：SonoVue组不同剂量组PI值均于MI=0．15时达最大值（P〈0．05）；相同MI下，高剂量组PI值较大。Sonazoid组不同剂量组PI值均于MI=0．40时达最大值（P〈0．05）；相同MI下，高剂量组PI值较大。结论SonoVue与Sonazoid显像条件不同，临床使用中需兼顾造影剂剂量、MI值及频率的影响。

Objective To compare the contrast enhancement effects of SonoVue and Sonazoid in rabbit liver at ultrasonic frequency of 7 MHz using various mechanical index（MI） and dosage. Methods Eight rabbits were bolus injected with different contrast agents：for SonoVue（0.06 ml/kg,0.12 ml/kg）,MI ranging 0.10 - 0.55 ; while Sonazoid （0. 045 ml/kg, 0.09 ml/kg）, MI ranging 0.19 - 0.98. Quantitative analysis of ultrasonography was done using video-intensity analysis system, and peak intensity （PI） was compared. Results With the same frequency, in SonoVue group, for both dosage groups, PI reached maximum at MI= 0.15 （P 〈0.05）; with the same MI, PI of the high dosage group was higher （P〈0.05）. In Sonazoid group,for both dosage groups,PI reached maximum at MI = 0.40（ P 〈0.05） ;with the same MI,PI of the high dose group was higher （ P 〈0.05）. Conclusions The optimistic ultrasonographic conditions provided to SonoVue and Sonazoid are different. Dosage of contrast agents, MI and frequency need to be concerned.