3Chen WH, Lo WC, Lee JJ, et al. Tissue-engineered intervertebral disc and chondrogenesis using human nucleus pulposus regulated through TGF-betal in platelet-rich plasma[J]. J Cell Physiol, 2006, 209(3): 744-754.
4Konttinen YT, Kemppinen P, Li TF, et al. Transforming and epidermal growth factors in degenerated intervertebral discs [J]. J Bone Joint Surg Br, 1999, 81(6): 1058-1063.
5Sobajima S, Shimer AL, Chadderdon RC, et al. Quantitative analysis of gene expression in a rabbit model of intervertebral disc degeneration by real-time polymerase chain reaction[J]. Spine J, 2005, 5(1): 14-23.
6Moon SH, Gilbertson LG, Nishida K, et al. Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer: implications for the clinical management of intervertebral disc disorders [J]. Spine, 2000, 25 (20): 2573- 2579.
7Leo BM, Li X, Balian G, et al. In vivo bioluminescent imaging of virus-mediated gene transfer and transduced cell transplantation in the intervertebral disc [J]. Spine, 2004, 29 (8): 838- 844.
8Liu X, Li K, Song J, et al. Efficient and stable gene expression in rabbit intervertebral disc cells transduced with a recombinant baculovirus vector[J]. Spine, 2006, 31 (7): 732-735.
9Osada R, Ohshima H, Ishihara H, et al. Autocrine/paracrine mechanism of insulin-like growth factor-1 secretion, and the effect of insulin-like growth factor-1 on proteoglycan synthesis in bovine intervertebral discs[J]. J Orthop Res, 1996, 14(5): 690-699.
10Moon SH, Nishida K, Gilbertson LG, et ol. Biologic response of human intervertebral disc cells to gene therapy cocktail [J]. Spine, 2008, 33(17): 1850-1855.
2Chan SCW, Walser J, Ktppeli P, et al. Region specific response of intervertebral disc cells to complex dynamic loading:an organ culture study using a dynamic torsion - compression bioreactor [ J ]. PloS one,2013,8:72489.
3Gruber HE, Gordon B, Williams C ,et al. Vertebral endplate and disc changes in the aging sand rat lumbar spine: cross - sectional analysesof a large male and female population [ J ]. Spine, 2007,23 : 2529 - 2536.
4Rodriguez AG, Rodriguez - Soto AE, Burghardt AJ, et al. Morphology of the human vertebral endplate[ J]. J Orthop Res,2012,2:280-287.
5Le Maitre CL, Freemont AJ, Hoyland JA. Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc [ J ]. J Pathol, 2004,1:47 - 54.
6Le Maitre CL, Freemont AJ, Hoyland JA. Accelerated cellular senes- cence in degenerate intervertebral discs: a possible role in the patho- genesis of intervertebral disc degeneration [ J]. Arthritis Res Ther, 2007,3 : R45.
7Kim KW, Cbung HN, Ha KY, et al. Senescence mechanisms of nu- cleus pulposus chondrocytes in human intervertebral discs [ J ]. Spine J,2009,8:658 - 666.
8Sobajima S, Vadala G, Shimer A, et al. Feasibility of a stem cell therapy for intervertebral disc degeneration[ J]. Spine J,2008,6:888 - 896.
9Wells DJ'. Gene therapy progress and prospects: electroporation and other physical methods[ J]. Gene Ther, 2004.18 : 1363 - 1369.
10Ireland D. Molecular mechanisms involved in intervertebral disc de- generation and potential new treatment strategies [ J ]. Biosci Horiz, 2009,1:83 - 89.
