胡椒环的合成研究

Synthesis of 1,3-benzodioxole

在没有催化剂的条件下以邻苯二酚和二氯甲烷为原料在高压反应釜中合成了胡椒环。对反应溶剂、缚酸剂、反应温度、原料配比等工艺条件进行了优化,胡椒环的收率高达75%。同时首次确定了一种主要副产物的结构为四氧环醚类化合物。

1,3-Benzodioxole was first synthsized by reaction of catechol and dichloromethane without the presence of catalyst in high pressure reaction kettle.It was investigated the influence of solvent,acid binder （type,amount）,temperature and the mole ratio of the reactants on the reaction yield,and gave the optimized reaction condition in which the title compound was synthesized in 75%yield.The main byproduct（cyclic ether） was also first isolated and determined by ~1HNMR and MS.