垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的疗效观察

Curative effect of pituitary vasopressin combined Phentolamine treatment bronchiectasis with massive hemoptysis

目的 探讨垂体后叶素联合酚妥拉明治疗支气管扩张大咯血的疗效和不良反应.方法 将100例支气管扩张大咯血患者随机分为酚妥拉明联合垂体后叶素序贯静脉泵入组（治疗组）50例和酚妥拉明组（对照组）50例,用药期间密切监测两组患者的咯血变化情况、止血时间及药物的不良反应.结果 治疗组总有效率为94.0%（47/50）,高于对照组的82.0%（41/50）（χ^2=3.845,P＜0.05）;治疗组止血时间（3.2±1.0）d,低于对照组的（5.0±1.4）d（t=2.134,P＜0.05）;治疗组出现不良反应10例（20.0%）,与对照组的11例（22.0%）比较,差异无统计学意义（χ^2=1.897,P＞0.05）.结论 垂体后叶素联合酚妥拉明治疗支气管扩张大咯血临床疗效显著,不良反应少.

Objective To study the curative effect and adverse reactions in bronehiectasis with massive hemoptysis.Methods 100 cases were randomly divided into pituitary vasopressin combined phentolamine treatment （treatment group）50 cases and phentolamine treatment（control group）50 cases.The hemptysis condition,hemostatic time and adverse reaction during the administration were detected.Results The total effective rate 94.0%（47/50）in treatment group were hishter than that control group 82.0%（41/50）（χ^2=3.845,P〈0.05）;Time to stop bleeding（3.2 ±1.0）days in treatment group were lower than the control group（5.0±1.4）days（t=2.134,P〈0.05）;Adverse reactions in treatment group were 10 cases（20.0%）,compared with control group 11 patients（22.0%）there were no significant difference（χ^2=1.897,P〉0.05）.Conclusion Pituitary vasopressin combined phentolamine to treatment massive hemoptysis had significant clinical effect with less adverse reaction.