普拉克索联合左旋多巴／苄丝肼治疗晚期帕金森病的疗效观察

Observation of the effect of pramipexole combined with levodopa/benserazide in treatment of advanced Parkinson＇s disease

目的 评估盐酸普拉克索联合左旋多巴/苄丝肼治疗晚期帕金森病的临床疗效.方法 50例患者随机分为治疗组25例、对照组25例.对照组给予左旋多巴/苄丝肼片和安慰剂,疗程16周;治疗组给予盐酸普拉克索片、左旋多巴/苄丝肼片,疗程16周.观察两组临床疗效.结果 与对照组比较,治疗组帕金森病评定量表评分显著下降,临床疗效明显提高（P＜0.05）,治疗组显效率（84.0%）高于对照组（36.0%）（χ^2=10.08,P＜0.01）.结论 盐酸普拉克索联合左旋多巴/苄丝肼治疗晚期帕金森病效果满意,值得推广应用.

Objective To evaluate the efficacy of pramipexole and levodopa/benserazide in treatment of advanced Parkinson＇s disease.Methods 50 patients with advanced Parkinson＇s disease were randomly divided into two groups,25 cases in the control group,others in the treatment group.The patients in the control group were treated with levodopa/benserazide and placebo,while those in the treatment group were given pramipexole and levodopa/benserazide.The treatment lasted 16 weeks.The clinical effects before and after the treatment were observed and compared. Results Compared with the control group,the treatment group experienced significant drops in the score of the Unified Parkinson＇s Disease Rating Scale（UPDRS）（P〈0.05）.The clinical efficacy was significantly improved（84.0%vs36.0%）（χ^2=10.08,P〈0.01）.Conclusion The clinical effect of pramipexole and levedopa/benserazide in treatment of advanced Parkinson＇s disease was satisfactory,and it should be widely applied.