首发抑郁症患者重复神经心理测查系统临床应用研究

Analysis of repeatable battery for the assessment of neuropsychological status（RBANS） in first-episode depression patients

目的 用重复神经心理测查系统（RBANS）和Stroop色词测验探讨首发抑郁症的认知功能损害特点.方法 采用重复神经心理测查系统（RBANS）和Stroop色词测验分别对230例首发抑郁症患者和178例健康对照进行检测.结果 在Stroop色词测验中,抑郁症患者完成单字、单色、双字、双色所需要的时间[（14.37±6.65）s,（21.58±8.70）s,（16.56±8.23）s,（37.88±13.67）s]均长于对照组[（12.38±3.34）s,（18.01±5.51）s,（14.17±4.37）s,（32.87±10.28）s],差异有显著性（P＜0.05）,但颜色干扰、字义干扰两组的结果没有明显差异,无统计学意义（P＞0.05）.在RBANS测查中,抑郁症患者5个因子所得的分数[（72.19 ± 17.22）分,（80.89 ± 15.29）分,（82.00±16.37）分,（98.74±17.01）分,（82.09±14.62）分]均差于对照组,且差异有统计学意义（P＜0.05）.相关分析显示,RBANS总分及5因子与HAMD总分及各因子相关无统计学意义;与教育程度正相关（P＜0.05）,与性别相关无统计学意义（P＞0.05）.RBANS总分及5因子中的即刻记忆、言语功能、延时记忆分别与年龄、病程呈负相关（P＜0.05）.而视觉广度、注意与年龄、病程相关无统计学意义（P＞0.05）.结论 首发抑郁症患者存在比较严重的记忆、注意、执行功能等全面认知功能的损害.

Objective To investigate the damaging traits of cognitive function in first episode depression patients with the assessment of neuropsychological status （ RBANS） and Stroop Color-word Test. Methods Two hundred and thirty first-episode depression patients as experimental group and one hundred and seventy-eight health person as control were evaluated separately by repeatable battery for the RBANS and Stroop Color-word Test. Results In Stroop Color-word Test,the time required for completing the words,color,double-word,two-color in depression patients （ （14.37 ±6.65）s,（21. 58 ±8. 70） s,（ 16. 56 ±8. 23）s, （37. 88 ± 13. 67） s） were longer than the control group （（12.38 ±3.34）s, （18.01 ±5.51） s, （14. 17 ±4. 37） s, （32. 87 ± 10.28） s）. The difference between the two groups was found in cognitive function in first episode depression patients （P 〈 0.05）. The scores of color interference and meaning interference were no difference between the two groups （P〉0.05） . The patients＇scores of the RBANS test in all items（ （72.19 ± 17.22）, （80.89 ± 15.29）, （82.00 ± 16.37） , （98.74 ± 17.01） ,（82.09 ± 14.62） ）were significantly poorer than those in healthy controls. Compared with control group, scores of the scales were significant difference between two groups. Pearson correlation analysis showed that RBANS total score and five factors had no correlation with HAMD total score and factors. It positively correlated with education level （P〈0.05） ,but not with sex （P〉0.05）. Immediate memory,verbal function,delayed memory in five factors and RBANS total score negatively correlated with age and course of disease respectively, but breadth of vision,attention were not did（P〈0.05）. Conclusion First-episode depression patients suffer from more serious and comprehensive damage of cognitive function such as memory,attention,executive function.