C-反应蛋白对慢性肾功能衰竭患者预后的影响

Influence of C-reactive protein on prognosis of patients with chronic renal failure

目的探讨C-反应蛋白(CRP)对慢性肾功能衰竭患者预后的影响。方法筛选安阳市人民医院肾内科2006年1月至2006年12月间住院慢性肾功能衰竭期、尿毒症期患者,入院后给予慢性肾功能衰竭标准治疗及对症治疗,第2天测定血浆高敏C-反应蛋白(hs-CRP)浓度。将入选者分为hs-CRP≤3 mg/L与hs-CRP>3 mg/L两组,分析两组3年再住院率及病死率。调整临床危险因素后,使用卡方检验评价CRP对慢性肾功能衰竭患者预后的影响。结果 112例入选者中67%hs-CRP>3 mg/L,其3年病死率高于hs-CRP≤3 mg/L组患者(P=0.03),3年再住院率两组间比较差异无统计学意义(P=0.24)。结论 CRP与慢性肾功能衰竭患者不良预后相关。

Objective To investigate the influence of C-reactive protein on prognosis of patients with chronic renal failure.Methods We screened patients at a renal failure stage or urinamia stage,admited between January 2006 and December 2006.Primary care providers coordinated standard treatment for chronic renal failure and other medical disorders.Plasma levels of hs-CRP were measured.The patients were divided into two groups： one group with hs-CRP level ≤3 mg/L and another group with hs-CRP 3 mg/L.We assessed 3-years all-cause mortality and and rehospitalization rates after hs-CRP level measurement.Chi-square test was used to evaluate the prognostic value of CRP after adjustment for clinic risk factor.Results Of 112 patients screened,67% had a 3 mg/L CRP level.The 3-years mortality of hs-CRP3 mg/L group was higher than that of hs-CRP≤3 mg/L group（P=0.032）.There was no significant difference of 3-year rehospitalization rate between the two groups（P=0.24）.Conclusion C-reactive protein is associated with a poor prognosis of chronic renal failure.