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西地那非治疗男性勃起功能障碍1200例临床应用体会 被引量:2

Clinical experience of sildenafil oral therapy for male erectile dysfunction
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摘要 目的 评价口服西地那非治疗勃起功能障碍(ED)的疗效.方法 1200例ED患者服用西地那非治疗,其中心理性ED 789例(65.75%),器质性ED 162例(13.50%),混合性ED 249例(20.75%).结果 经服用西地那非治疗1006例取得有效和显效,总有效率83.83%,其中心理性ED 95.06%(750/789)、器质性ED 66.05%(107/162)、混合性ED 59.84%(149/249),本组口服西地那非治疗ED无重大不良反应发生.结论 西地那非为口服治疗ED一线药物,安全有效. Objective To evaluate the efficiency of sildenafil oral therapy for male erectile dysfunction(ED). Methods Total of 1 200 patients with ED including 789 psychological ED, 162 organic ED and 249 mixed ED were treated with oral sildenafil. Their effects were retrospectively analyzed. Results The total efficacy rate was 83.83% (1 006 patients). There were no severe adverse events during treatment. Conclusion Sildenafil is a well-tolerated and effective oral medicine for treatment of patients with erectile dysfunction.
出处 《中国男科学杂志》 CAS CSCD 2011年第2期35-38,共4页 Chinese Journal of Andrology
关键词 西地那非 勃起功能障碍/药物疗法 sildenafil erectile dysfunction/drug therapy
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参考文献11

  • 1姜辉.勃起功能障碍的定义、流行病学及危险因素.见:中华医学会男科学分会主编.勃起功能障碍、阴茎异常勃起诊治指南.2006:1
  • 2西地那非Ⅳ期临床研究组.西地那非治疗勃起功能障碍的安全性和疗效的临床应用研究[J].中华泌尿外科杂志,2003,24(2):134-137. 被引量:16
  • 3Porst H,Ahlen HV,Vahlensieck W.Relevance of dynamic cavernosography to the diagnosis of venous incompetence in erectile dysfunction.J Urol 1987;137(6):1163-1167.
  • 4Koskimaki J,Hakama M,Huhtala H,et al.Effect of erectile dysfunction on frequency of intercourse:a populationbased prevalence study in finland.J Urol 2000;164(2):367-370.
  • 5Kinsey AC,Pomeroy WB,Martin CB.Sexual behaviour in the human male.Philadelphia:WB Saunder,1948:84.
  • 6Boolell M,Attee G,Gingell JC,et al.Sildenafil,a novel effective oral therapy for male erectile dysfunction.Br J Urol 1996;78(2):257-261.
  • 7Selvin E,Burnett AL,Platz EA.Prevalence and risk factors for erectile dysfunction in the US.AMJ 2007;120(2):151-157.
  • 8Hatziehristou DG,Apostolidis A,Tzortzis V,et al.Sildenafil versus intracavernous injection therapy:efficacy and preference in patients on intraeavernous injection for more than 1 year.J Urol 2000;164(4):1197-1200.
  • 9Arslan D,Esen A,Secil M,et al.A new method for the evaluation of erectile dysfunction:sildenafil plus Doppler ultrasonography.J Urol 2001;166:181-184.
  • 10Cieslik K,Abrams CS,Wu KK.How does Viagra protect the ischemic heart.Am J Cardiovasc Drugs 2008;8:1-7.

二级参考文献11

  • 1Rhodes PR, Krogh RH, Bruskewitz RC. Impact of drug therapy on benign prostatic hyperplasia-specifie quality of life. Urology 1999; 53(2): 1090-1098.
  • 2Hieble JP, Bylund DB, Clarke DE, et al. International union of pharmacology X.recommendation for nomenclature of α 1-adrenceptors consensus update. Pharmacol Rev 1995; 47(2): 267-269.
  • 3Nasu K, Moriyama N, Fukasawa R, et al. Quantification and distribution of α 1-adrenceptor subtype mRNAs in human proximal urethra. Br J Phramacol 1998; 123 (7):1289-1293.
  • 4Takei R, Ikegaki I, Shibata K, et al. Naftopidil, a novel α1-adrenceptor antagonist, displays selective inhibition of canine prostatic pressure and high affinity binding to cloned human α 1-adrenceptors. Jpn J Phamacol 1997;79(4): 447-454.
  • 5Niebch G, Locher M, Borbe HO. Metabolic fate of the novel antihypertensive drug naftopidil. Arzneimittelforschung 1991; 41(10): 1027-1032.
  • 6Takagi N, Ishii M, Takeda K, et al. Pharmacokinetics of naftopidil (KT-611) in hypertensive patients with renal impairment or normal renal function. J Clin Ther Med 1992; 8(3): 109-122.
  • 7Farthing MJ, Alstead EM, Abrams SM, et al, Pharmacokinetics of naftopidil, a novel anti-hypertensive drug,in patients with hepatic dysfunction. Postgrad Med J 1994; 70 (2):363-366.
  • 8Yasuda K, Yamanishi T, Tojo M, et al. Effrct of naftopidil on urethral obstruction in benigh prostatic hyperplasia;assessment by urodynamic studies. Prostate 1994; 25(1): 46-52.
  • 9郭应禄,朱积川,潘天明,曹坚,江鱼,王益鑫,姚德鸿,胡礼泉.口服西地那非治疗勃起功能障碍疗效和安全性的临床研究[J].中华泌尿外科杂志,2001,22(7):389-394. 被引量:53
  • 10何志嵩,金杰,那彦群,郭应禄.α受体阻滞剂对良性前列腺增生患者症状的影响作用[J].中华泌尿外科杂志,2002,23(6):358-360. 被引量:19

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同被引文献26

  • 1Naito H, Sasaki M, Nakamura K, et al. Urinary and sexual dysfunction after rectal cancer operation. Nihon Gan Chiryo Gakkai Shi 1990; 25(3): 559-568.
  • 2Mancini R, Cosimelli M, Filippini A, et al. Nerve-sparing surgery in rectal cancer: feasibility and functional results. J Exp Clin Cancer Res 2000;19(1): 35-40.
  • 3La Monica G, Audisio RA, Tamburini M, et al. Incidence of sexual dysfunction in male patients treated surgically for rectal malignancy. Dis Colon Rectum1985; 28(12): 937-940.
  • 4Van Kampen M, De Weerdt W, Claes H, et al. Treatment of erectile dysfianction by perineal exercise, electromyographic biofeedback, and electrical stimulation. Phys Ther 2003; 83(6): 534-543.
  • 5Hoekx L, Wyndaele J J, Vermandel A. The role of bladder biofeedback in the treatment of children with refractory nocturnal enuresis associated with idiopathic detrus or instability and small bladder capacity. J Urol 1998; 160(3Pt 1): 8580-8601.
  • 6Yeager ES, Van Heerden JA. Sexual dysfunction following proctocolectomy and abdominoperineal resection. AnnSurg 1980;191(2):169 -170.
  • 7Santangelo ML, Romano C, Sassarol C. Sexual function after resection for rectal cancer. Am J Surg1987;154 (5): 502- 504.
  • 8Clemens JQ, Nadler RB,Schaeffer AJ, et al. Biofeedback, pelvic floor reeducation, and bladder training for male chronic pelvic pain syndrome. Urology 2000; 56(5): 951.
  • 9Cornel EB, van Haarst EP, Schaarsberg RW, et al. The effect of biofeed-back physical therapy in men with Chronic Pelvic Pain Syndrome Type III. Eur Uro12005; 47(5): 607-611.
  • 10Ekmekcioglu O, Inci M, Demirci D, et al. Effects of sildenafilcitrate on ejaculation latency, detumescence time, and refi'actory period: placebo-controlled, double-blind, crossover laboratory setting study. Urology 2005; 65 (12): 347-352.

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