松馏油药浴联合窄谱中波紫外线照射治疗寻常性银屑病疗效观察

Observation on Therapeutic Effect of Pine Tar Baths Combined with Narrow-band Ultraviolet B in the Treatment of Psoriasis Vulgade

目的:观察10%松馏油药浴联合窄谱中波紫外线(NB-UVB)照射治疗寻常性银屑病的临床疗效。方法:将入选的240例寻常性银屑病患者随机分成3组,对照1组予以NB-UVB全身照射;对照2组予以10%松馏油泡浴20 min,并淋浴冲洗擦干后即可:治疗组予以10%松馏油泡浴后联合NB-UVB照射。三组均隔日治疗1次,10次为1个疗程,连续治疗2个疗程后判定疗效。结果:治疗组有效率(95.78%)优于对照1组(85.26%)和2组(66.00%),且治疗组PASI评分(3.85±4.76)显著低于对照1组(5.61±3.45)和对照2组(8.41±3.92),差异均有统计学意义(P<0.01)。但治疗组的不良反应发生率明显高于对照1组(P<0.05),对照2组未出现不良反应。结论:10%松馏油药浴联合窄谱中波紫外线照射治疗寻常性银屑病疗效好,能较快缓解病情。

Obective To observe the efficacy of pine tar baths combined with narrow-band ultraviolet B（NB-UVB）in the treatment of psoriasis vulgaris.Methods 240 patients with psoriasis vulgaris were randomly divided into three groups as following：control group 1 was treated with NB-UVB,control group 2 was treated with pine tar baths for twenty minutes,treatment group was treated with pine tar baths combined with NB-UVB.Treated was given once every other day,and one course for ten times.Treatment assessment was carried out after two courses,which was based on efficiency and the Psoriasis Area and Severity lndex（PASl） score.Results The effective rate of the treatment group was 95.78%,and other two control group was 85.26%and 66.00%,respective.The PASI score in treatment group （3.85±4.76） is significantly lower than the control group l （5.61±3.45）and the control group 2（8.41±3.92）,the differences were statistically （P0.01）.Besides,untoward reaction incidence rate in the treatment group was higher than those in control group l（P0.05）,while no adverse event had been observed in control group2.Conclusion Combining pine tar baths with NB-UVB is an efficacy topically applied agent in the treatment of psoriasis vulgaris.