IL-6与支原体胎盘炎关系的研究

Study on the relationship between the interleukin-6 and the mycoplasma placental inflammation

目的:观察支原体宫颈炎孕妇血清中IL-6水平变化,应用产后胎盘病理检查结果进行验证,求证IL-6对支原体胎盘炎的诊断价值。方法:将受试者分成宫颈支原体阴性组(正常孕妇组)、宫颈支原体阳性组。对两组孕妇血清IL-6水平进行定量检查,分别计算其平均值;对两组孕妇做产后胎盘病理检验,分别计算胎盘绒毛膜羊膜炎的发生率;对宫颈支原体阳性组做产后胎膜支原体培养,计算支原体感染胎盘炎的发生率。结果:宫颈支原体阳性组胎盘绒毛膜羊膜炎的发生率为37.25%,宫颈支原体阴性组为41.54%,两组差异无统计学意义(P>0.05),宫颈支原体阳性组中孕妇胎盘出现绒毛膜羊膜炎,胎膜支原体培养阳性,其血清IL-6明显升高,两组比较有统计学差异(P<0.05)。结论:孕妇血清中IL-6检测可以预测支原体胎盘炎。

Objective： To observe the mycoplasma cervicitis in maternal serum levels of IL- 6, with postnatal placental pathology for authentication, verify diagnostic value of IL - 6 on mycoplasma placental inflammation. Methods ： The participants were divided into two groups, cervical mycoplasma negative group （control group） and cervical mycoplasma positive group （research group） . Quantitative check of two sets of IL - 6 in serum of pregnant women, whose average was calculated separately ; Postpartum placental pathology were examined in the two groups of pregnant women and the incidence of placenta chorioamnionitis were calculated separately ; Postpartum mycoplasma cultures were done in cervical mycoplasma positive group, prevalence of chlamydial placental inflammation were calculated. Results： The incidence of nlacental chorioamnionitis was 37. 25% in cervical mycoplasma positive group, control group was 41. 54% , the two group had no significaut differences （P 〉 0. 05） ; Placentas chorioamnionitis occured in cervical mycoplasma positive group, mycoplasma was positive in fetal membranes, the serum IL-6 significantly increased, there was significant difference between the two groups （ P 〈0 . 05） . Conclusion： IL-6 detection in patients with mycoplasma can predict the placenta inflammation.