手机使用与听神经瘤风险关系的Meta分析

Metaanalysis of Mobile Phone Use and the Association with Acoustic Neuroma

[目的]研究手机使用与听神经瘤发病风险的关系,探讨手机使用的安全性。[方法]在线检索文献资料,分析手机使用与听神经瘤发病风险关系的病例对照研究,采用随机效应模型计算合并OR值,Meta回归筛选异质性影响因素,进行亚组分析。[结果]共纳入8篇文献,包括1527例听神经瘤患者和7636例对照。各研究存在异质性,随机效应模型结果表明,手机使用、长期使用与听神经瘤发病风险均无统计学关联,合并OR值分别为0.93(95%CI:0.75～1.16)和1.35(95%CI:0.81～2.25)。经Meta回归分析,以地区为异质性影响因素,做亚组分析。两亚组使用手机对听神经瘤的风险均未发现有显著影响,合并OR值分别为0.88(95%CI:0.77～1.00)和1.09(95%CI:0.80～1.51)。长期使用手机使听神经瘤发病风险增加,合并OR值分别为1.39(95%CI:1.12～1.73)和1.94(95%CI:1.30～2.89)。[结论]手机使用与听神经瘤的关联尚不能定论,但可能存在剂量—反应关系,需要进一步的研究。

[Purpose] To investigate the relationship between mobile phone use and risk for acoustic neuroma and to evaluate the adverse effect of cell phone use.[Methods] According to the online search of relevant case-control study on the relationship between mobile phone use and the risk for acoustic neuroma,random effects estimation was used to assess pooled odds ratios.Meta-regression and subgroup analysis were used for heterogeneity analysis.[Results] A total of 8 studies were included in this Meta-analysis,including 1 527 cases with acoustic neuroma and 7 636 controls.Use or frequently use of a cellular phone was not associated with acoustic neuroma,with pooled odds ratio 0.93（95%CI：0.75~1.16） and 1.35（95%CI：0.81~2.25） respectively.Area was selected as a factor of heterogeneity according to Meta-regression,and the included 8 studies were separated into two subgroups.No significant associations were found between regular cell phone use and risk of acoustic neuroma in two subgroups,with pooled odds ratio 0.88（95%CI：0.77~1.00） and 1.09（95%CI：0.80~1.51）.Elevated ORs were observed in two subgroups for long-term mobile phone use,with pooled odds ratio 1.39（95%CI：1.12~1.73） and 1.94（95%CI：1.30~2.89） respectively.[Conclusion] The relationship between mobile phone use and acoustic neuroma couldn＇t be concluded.A potential dose-response relationship between cell phone use and acoustic neuroma might exist.Further studies are needed to evaluate the side effect of cell phone use.