摘要
目的:探讨环氧合酶-2(COX-2)在不同病理类型非霍奇金淋巴瘤(NHL)组织中的表达及其与患者临床特征的关系。方法:采用免疫组织化学EnVision二步法检测96例NHL和20例恶性肿瘤患者切除组织中未累及之淋巴结中COX-2的表达,回顾性分析患者的分期、分组、结外侵犯等临床特征。结果:COX-2在NHL中的阳性表达率为39%(37/96),对照组为15%(3/20),差异有统计学意义(P<0.05)。不同病理类型之间COX-2表达差异有统计学意义(P<0.01),其中鼻型结外NK/T细胞淋巴瘤、黏膜相关淋巴组织结外边缘区淋巴瘤(MALT淋巴瘤)、血管免疫母细胞T细胞淋巴瘤组织中COX-2阳性率分别为83%(10/12)、71%(5/7)和57%(4/7)。有结外侵犯的患者COX-2阳性率显著高于无结外侵犯者(P<0.01),有无B组症状的NHL患者之间COX-2阳性率差异有统计学意义(P<0.05)。结论:NHL中COX-2表达上调,但不同病理类型之间COX-2表达差异较大,高表达COX-2的NHL患者易于出现结外侵犯及B组症状。
Objective:To investigate the expression of cyclooxygenase-2(COX-2) in various pathological subtypes of non-Hodgkin′s lymphoma(NHL) and its relationship with clinical features.Method: Immunohistochemical EnVision method was used to detect the expression of COX-2 in 96 samples of NHL and 20 uninvolved lymph nodes from patients with malignant tumour.The clinical features of gender,age,Ann Arbor stage,B symptoms,extranodal involvement were analyzed.Result: COX-2 expression was found in 37 of 96 patients(39%) with NHL,while control group only had a positive rate of 15%(3/20)(P0.05).The difference of COX-2 expression among various subtypes of NHL was highly significant(P0.01).The positive rates of COX-2 in extranodal NK/T-cell lymphoma,nasal type,MALT lymphoma and angioimmunoblastic T-cell lymphoma were 83%(10/12),71%(5/7) and 57%(4/7),respectively.The expression of COX-2 was related with extraonodal involvement(P0.01) and B symptoms(P0.05).Conclusion: NHL tissues over-expressed COX-2,but there were significant differences among various subtypes.Patients with COX-2 expression tended to show extraonodal involvement and B symptoms.
出处
《临床血液学杂志》
CAS
2011年第3期286-289,共4页
Journal of Clinical Hematology