106例新生儿缺氧缺血性脑病血清酶学变化分析

Changes of serum enzymes in 106 neonates with hypoxic ischemic encephalopathy

目的探讨新生儿缺氧缺血性脑病(HIE)的发生、程度和预后与血清酶学变化的临床相关性。方法回顾中、重度HIE患儿106例血清酶学检测的结果。结果所有患儿均有血清酶活性不同程度升高,中、重度各酶值比较差异有统计学意义(P<0.05)。结论血清酶学变化测定对新生儿缺血缺氧性脑病早期诊断及预后有指导意义,可降低后遗症发生率和患儿病死率。

Objective To investigate the correlation of the occurrence,extent and prognosis of neonatal hypoxic ischemic encephalopathy（HIE） with the changes of serum enzymes.Methods The data of serum enzymes in 106 neonates with moderate or severe HIE were analyzed retrospectively.Results The activities of serum enzymes were increased in various degrees in all the patients,and there was a significant difference between the moderate and severe patients（P0.05）.Conclusions The determination of the changes of serum enzymes is helpful in early diagnosis and the judgment of prognosis,and may reduce the incidence of sequelae and mortality in neonates with HIE.