摘要
目的:研究大鼠注射施普睿达注射液后的血药浓度和药动学特征。方法:大鼠尾静脉注射施普睿达注射液低、中、高3个剂量(50,100,200 mg·kg^(-1))后检测不同时间血浆中施普睿达的浓度,并估算其药物动力学参数。结果:大鼠单次静注给予注射用施普睿达后,主要药动学参数t_(1/2)分别为0.43,0.37,0.41 h;AUC_((0～∞))分别为91.12,172.65,280.02 mg·h·L^(-1);C_(max)分别为261.23,433.79,751.22 mg·L^(-1)。结论:该法适于药物动力学考察。大鼠体内注射用施普睿达在50～200 mg剂量范围内呈线性药物动力学特征。
Objective： To determine sprida and the pharmacokinetics in rat plasma by RP-HPLC. Method： Rat plasma samples were collected and pharmacokinetic parameters of sprida were estimated after a single dose of sprida injection. Result. The pharmacokinetic results showed that t1/2 were 0. 43, 0. 37 and 0. 41 h for three doses with AUC（0-∞） of 91.12, 172. 65 and 280. 02 mg·h·L^-1 and Cmax of 261.23,433.79 and 751.22 mg· L^-1 , respectively. Conclusion： The pharmaceutical characteristics of sprida injection in rats were linear within the range of 50-200 mg. The established HPLC method is suitable for the pharmacokinetic study of sprida in plasma after iv administration of three doses of sprida injection.
出处
《中国药师》
CAS
2011年第5期631-633,共3页
China Pharmacist
基金
放射医学研究所探索基金(编号:ST1017)
