补脾益肠膏煎煮工艺优选

Study on Decoction Process of Bupi Yichang Electuary

目的:优选补脾益肠膏煎煮工艺。方法:采用正交设计法,以盐酸小檗碱含量和干膏得率为考察指标,优选补脾益肠膏煎煮工艺。结果:补脾益肠膏最佳煎煮工艺为:加12倍量水,浸泡4 h,回流提取3次,第一次2 h,第二、三次各0.5 h;按正交试验优选条件进行结果投料3份次验证实验,平均浸膏得率为29.8%,盐酸小檗碱平均含量为5.77 mg·g^(-1)。结论:优选的煎煮工艺科学合理,适合于制剂生产。

Objective： To optimize the decoctiort process of Bupi Yiehang electuary. Method： The process was optimized on basis of the content of berberine hydroehloride and yield of dry extract by orthogonal desisn. Result： The optimal conditions were presented as follows： soaking the medicinal materials in water which was 12-fold of their weight for 4h, reflux extracted for three times, the first time for 2 h, the others for 0. 5 h each. Demonstrating test was carried out by 3 batches feeding according to the results of the orthogohal design, and the average yield of extract was 29.8% and the average content of berberirte hydrochloride was 5.77 mg·g ^-1. Conclusion： The result shows that the optimized decoction process is scientific and reasonable in the preparation production.