重组人白细胞介素-11致严重双下肢水肿

Severe edema in the lower extremities due to recombinant human interleukin-11

1例61岁男性患者,因小细胞肺癌化、放疗期间出现血小板减少,给予重组人白细胞介素-11(rhIL-11)3 mg,1次/d,皮下注射。给药第5天患者出现双下肢轻度水肿,第7天发展为重度水肿。考虑水肿与rhIL-11有关,立即停用rhIL-11,给予氢氯噻嗪、螺内酯利尿治疗。停药2 d后患者水肿逐渐消退。2个月后患者再次出现血小板减少,再给予皮下注射rhIL-11,3 mg/d,给药5 d后患者再次出现双下肢轻度水肿,停用rhIL-11,2 d后水肿消退。

A 61-year-old male patient with small cell lung cancer received SC recombinant human interleukin-11（rhIL-11） 3 mg once daily for thrombocytopenia which occurred during chemotherapy.On day 5 of drug therapy,the patient presented with mild edema in his lower extremities,which progressed to a severe edema on day 7.The edema was considered to be related to rhIL-11.The drug was discontinued immediately.The man received diuretic therapy with hydrochlorothiazide and spironolactone.Two days after drug withdrawal,his edema gradually diminished and then subsided.Two months later,his thrombocytopenia recurred.SC rhIL-11 3 mg/day was readministered.Five days after initiation of rhIL-11,mild edema in his lower extremities recurred.His edema subsided two days after discontinuation of rhIL-11.