麋鹿角不同部位对于甲亢阴虚症大鼠的作用及其机制初探

Nourishing-Yin Effect and Mechanism of Different Parts of Cornu Elaphuri Davidiani in Rats

目的:观察麋鹿角不同提取部位对甲亢阴虚大鼠的影响及其作用机制。方法:采用甲状腺素造成大鼠甲亢阴虚症模型,通过考查模型动物的物质代谢、痛阈值、血清中内分泌激素水平及血清生化指标的变化,观察麋鹿角不同提取部位对阴虚大鼠的作用,并初步探讨其机制。结果:麋鹿角醇提部位对于甲亢阴虚症模型大鼠有明显的补阴功效,能显著调节阴虚大鼠的物质代谢、提高其痛阈值,并能调节血清中内分泌激素水平、提高抗氧化能力。结论:麋鹿角醇提部位对于阴虚症大鼠有明显疗效,其补阴功效与其调节神经内分泌网络功能密切相关。

Objective：To investigate nourishing-yin effect and mechanism of different parts of Cornu Elaphuri Davidiani in rats.Method：The model of yin asthenia rats was built by thy roxine.The substance metabolism,pain threshold,hormone levels and biochemical indicators in serum were measured.Results：The ethanol extract of Cornu Elaphuri Davidiani could regulate the substance metabolism and raise the pain threshold in yin asthenia model rats.Furthermore,it could regulate the hormone levels,biochemical indicators in serum and it could improve the antioxidant ability.Conclusion：The ethanol extract of Cornu Elaphuri Davidiani showed significant nourishing-yin effect in rats and the possible mechanism is correlated with regulating the neuroendocrine network.