单面针茎中生物碱类成分研究

Study on the Alkaloids from the Stem of Zanthoxylum dissitum

目的：对单面针茎中的生物碱成分进行研究。方法：将0.5%盐酸渗滤得到酸水用氨水调pH值至11,以此提取单面针茎中总生物碱,采用氧化铝、硅胶柱层析法进行分离,并根据理化性质及光谱数据对单体化合物进行结构鉴定。结果：分离得到4个化合物,经鉴定分别为：两面针碱（Ⅰ）、血根碱（Ⅱ）、花椒棚碱（Ⅲ）、白鲜碱（Ⅳ）。结论：其中,化合物Ⅰ~Ⅲ为首次从单面针茎中分离得到。

Objective：To study the alkaloids from the stems of Zanthoxylum dissitum.Methods：Added ammonia to the 0.5% HCl extract solution of the plants until the pH was 11 to collect the total alkaloids.Using the chromatography of alumina and silica gel to separate the alkaloids.According to the physicochemical properties and spectral analysis to elucidate the structures of the constitutes.Results：Four compounds were isolated and identified as nitidine（Ⅰ）,sanguinarine（Ⅱ）,zanthobungeanine（Ⅲ）,dictamnine（Ⅳ）.Conclusion：Besides dictamnine,three others are isolated from the rhizome of the plant for the first time.