HPLC法测定盐酸去氯羟嗪的有关物质

Determination of Related Substances in Decloxizine Hydrochloride by HPLC

目的:建立高效液相色谱法测定盐酸去氯羟嗪中的有关物质。方法:采用C18柱,以甲醇-水-三乙胺(42∶58∶0.5)(用磷酸调节pH值至3.0)为流动相,检测波长为225 nm。结果:盐酸去氯羟嗪与其降解产物在该色谱条件下能够有效分离。结论:方法简便、专属性强,可用于测定盐酸去氯羟嗪中有关物质。

Objective：To establish an HPLC method for determining related substances in Decloxizine Hydrochloride. Methods：Using HPLC with C18column, methanol-water-triethanolamine （42： 58： 0. 5） （adjusted to pH 3.0 with phosphoric acid） as the mobile phase and the detection wavelenghth at 225 nm. Results：Deeloxizine Hydrochloride and its related substance can be separated effectively by this method. Conclusion：The method is simple and reliable. Related substances in Decloxizine Hydroehloride can be determined by HPLC.