摘要
二新 cucurbitane 类型 triterpenoids，(23E )-5,19-epoxycucurbita-6,23,25-triene-3-ol (1 ) 并且(19R， 23E ) 和三已知的混合物， -5,19-epoxy-19-ethoxycucurbita-6,23-diene-3,25-diol (2 ) 从 Momordica charantia L 的水果被孤立。他们的结构被决定根据光谱分析。他们的细胞毒素的活动被 MTT 试金在 5 根癌症房间线， MCF-7， HepG2， Du145， Colon205 和 HL-60 上测试。加重 1， 3 和 4 显示出的弱 cytotoxicity。
Two new cucurbitane-type triterpenoids,（23E）-5β,19-epoxycucurbita-6,23,25-triene-3β-ol（1） and（19R,23E）-5/β,19-epoxy- 19-ethoxycucurbita-6,23-diene^3β,25-diol（2）,together with three known compounds,have been isolated from the fruit of Momordica charantia L.Their structures were determined on the basis of spectral analysis.Their cytotoxic activity was tested on 5 cancer cell lines,MCF-7,HepG2,Dul45,Colon205 and HL-60 by MTT assay.Compounds 1,3 and 4 showed weak cytotoxicity.
基金
supported by E&T Modern Center for Natural Products of Liaoning Province of China (No.2008402021)
