胶原蛋白海绵的性质及其临床应用(英文)

Properties and clinical application of collagen sponge

背景:胶原蛋白海绵具有良好的功能和特性,及其易于加工、灭菌和保存等独特的优势,被视为最有用途的生物材料,具有广泛的科研和临床应用价值。目的:介绍胶原蛋白海绵的性质,对近年来胶原蛋白海绵在临床应用上的研究成果进行综述。方法:由第一作者应用计算机检索2000-01/2010-08 Pubmed数据库和Elsevier数据库,在标题和摘要中以"collagen,collagen sponge,clinical application"为检索词进行检索。检索1993-01/2010-08CNKI数据库,在标题和摘要中以"胶原,胶原蛋白海绵,临床应用"为检索词进行检索。纳入38篇文献进行综合分析。结果与结论:胶原蛋白海绵作为一种新型生物材料,越来越广泛地被应用于止血、创面愈合、抗感染、软骨修复、神经修复等相关方面的组织工程与临床研究。但目前所使用的胶原几乎都是来源于动物,无法彻底消除免疫原性。国外已有人利用生物反应器和转基因技术合成了重组人胶原,其在临床应用上的有效性和安全性等问题仍有待进一步的探索和研究。

BACKGROUND：Collagen sponge is considered the most useful biomaterial owing to its excellent function and properties,easy processing,sterilization,and preservation and has been widely used in scientific research and clinical application.OBJECTIVE：To describe the properties of collagen sponge and to review the research progress of collagen sponge in clinical application in recent years.METHODS：A computer-based retrieval was performed by the first author to search for manuscripts published from January 2000 to August 2010 in Pubmeds and Elsevier databases and for manuscripts published from January 1993 to August 2010 in CNKI database using key words ＂collagen,collagen sponge,clinical application＂ in title and abstract items in English and Chinese language,respectively.RESULTS AND CONCLUSION：Collagen sponge,as a new biological material,has been widely applied in tissue engineering research in terms of hemostasis,wound healing,anti-infection,cartilage repair,and nerve repair.But at present,nearly all collagen is from animals and immunogenicity cannot be thoroughly eliminated.Researchers outside of China have synthesized recombinant human collagen using bioreactor and transgenic technology,but its efficacy and safety in clinical application needs further investigation and research.