干细胞参与运动损伤的组织修复

Stem cells involved in the tissue repair of sports injury

背景:既往多项研究已证实间充质干细胞具备多向分化潜力,并应用到多个领域,同样干细胞疗法对解决组织损伤修复将是一种革命性进步。目的:对国内外应用干细胞治疗软组织损伤的现状及新进展作一综述。方法:应用计算机检索CNKI和Elsevier数据库中2000-01/2010-09关于干细胞参与软组织损伤治疗的文章,在标题和摘要中以"干细胞,治疗,损伤"或"stem cells,treatment,Soft tis sues injure"为检索词进行检索。选择文章内容与干细胞治疗有关者,同一领域文献则选择近期发表或发表在权威杂志文章。最终选择关于干细胞治疗组织损伤的36篇文献进行综述。结果与结论:体育运动过程中导致的肌腱,骨骼损伤,难以根治,常反复发作,严重影响到运动员的竞技状态。干细胞技术的研究对治疗运动员的损伤无疑具有重大意义。目前以间充质干细胞为基础的细胞疗法正成为再生医学研究领域中的热点和最前沿,因此间充质干细胞作为最重要的成体干细胞来源,具有极其重要的应用前景。

BACKGROUND：Previous studies demonstrated that mesenchymal stem cells（MSCs） have the potential of multi-directional differentiation,and applied to many field.Stem cells therapy will be a revolutionary progress for tissue injury repairing.OBJECTIVE：To summarize the situation and new progress of soft tissue injury with stem cells therapy at home and abroad.METHODS：The articles related to stem cells involved in the treatment of soft tissue injury in CNKI database and Elsevier database from January 2000 to September 2010 were retrieved by computer with the Key wordsof ＂stem cells,treatment,soft tissues injury＂ in Chinese and in English.The content of articles related to stem cells therapy,and recently published or published in authoritative magazines in the same field were selected,and 36 documents of them were involved for summarization.RESULTS AND CONCLUSION：The competitive state of athletes was seriously affected by tendon,skeletal injury in sports,and it is difficult to radical cure,often recurrent attacks.The research of stem cells technology has a great significance in the treatment of injury of athletes.At present,MSCs as a basis of cells therapy is becoming a hot spot and most forward in the field of regenerative medicine research.Therefore,MSCs as the most important source of adult stem cells has a vital application prospect.