血清甲胎蛋白水平对重型病毒性肝炎预后影响的相关性研究

The Relations of Serum Alphafetoprotein Level and Prognosis in Severe Viral Hepatitis

目的:探讨血清甲胎蛋白(AFP)水平对重型病毒性肝炎预后的影响。方法:用放射免疫法测定368例重型病毒性肝炎患者血清AFP水平并动态观测其变化。结果:急性重型肝炎AFP异常率明显低于亚急性重型肝炎及慢性重型肝炎(p<0.01)。AFP水平正常患者的病死率79.24%,AFP(25-400)μg/L患者病死率45.84%,AFP>400μg/L患者病死率34.54%。368例重型病毒性肝炎存活170例,AFP水平(282.31±56.32)μg/L;368例重型病毒性肝炎死亡198例,AFP水平(90.42±38.88)μg/L,两者比较差异有显著统计学意义(p<0.01)。结论:重型病毒肝炎患者血清AFP测定可作为判断其预后的敏感指标,患者AFP水平高,说明其肝细胞再生活跃,预后相对较好。

Objective：The nbjective of this study was to explore the relations of quantitatively measures of serum alphaferoprotein （AFP） and prognosis in severe viral hepatitis. Methods：The level of blood serum AFP was determined by radioimmunassay in 368 cases with gravis type viral hepatitis, and its change was observed in a dynamic rate. Results：The abnormity rate of AFP was 71.19% , the abnormity rate of AFP in ae.ute severe hepatitis patients was significantly less than that in sub-acute severe hepatitis and chronic severe hepatitis（p 〈0.01） , the death rate of patients with AFP 〈 2ug/L, AFP20 - 400ug/L and AFP 〉 400ug/L was 79. 24% , 45.84% and 34. 054% respectively, the survival severe hepatitis patients were 170 cases with AFP（ 282.31 ± 56.32）ug/l, in 368 cases, 198 cases with AFP（ 90.42 ± 38.88）ug/L died（p 〈0.01 ）. Conclusion：The blood serum AFP determination in gravis type viral hepatitis can be used as a sensitive index for prognosis. A high level of AFP indicates that hepatitis cells regeneration is active and the prognosis is relatively better.