戊酸雌二醇用于宫腔粘连分离术后防止再粘连的研究

Study of estradiol valerate for prevention of uterine adhesion after hysteroscopic adhesiolysis

目的:评价戊酸雌二醇(Estradiol valerate,E2V)用于术后防止宫腔粘连复发的效果。方法:宫腔镜下行宫腔粘连分离术和放置宫内避孕环后的患者,15例不用E2V,15例用E2V(9 mg/d)2月,15例用E2V(9 mg/d)3月。所有病例定期随诊,治疗结束后取出宫内避孕环,同时再行宫腔镜检查。结果:完成治疗后,用E2V3月组子宫内膜厚度最厚,不用E2V组最薄。宫腔形态及月经恢复正常率,用E2V 3月组达93.3%,用E2V 2月组达73.3%,而不用E2V组46.7%。结论:宫腔镜下宫腔粘连分离术后,同时口服E2V是防止宫腔粘连复发的有效方法。

Objective： To evaluate the effects of estradiol valerate（E2V） on prevention of uterine adhesion after hysteroscopic adhesiolysis.Methods：After hysteroscopic adhesiolysis was performed and the intrauterine devices（IUDs） were put,fifteen patients weren＇t treated with E2V,fifteen patients were treated with E2V（9 mg daily）for two months,and another fifteen patients were treated with E2V（9 mg daily）for three months.All cases were followed up.IUDs were taken out when treatment was finished and a second time hysteroscopy was performed.Results： When treatment was finished,the endometria of E2V for three months group were the thickest,and the no E2V group was the thinnest.In regard to the shape of uterine cavity and the return of menstruation to normal,E2V for three months group was 93.3%,E2V for two months group was 73.3%,and the no E2V group was only 46.7%.Conclusion： E2V is effective for the prevention of uterine adhesion after hysteroscopic adhesiolysis.