Livin和Smac在尖锐湿疣组织中的表达

Expressions of Livin and Smac in condyloma acuminatum tissue

目的探讨凋亡抑制蛋白Livin和促凋亡因子Smac在尖锐湿疣组织中的表达及意义。方法采用免疫组化sP法检测58例尖锐湿疣组织中Livin和Smae的表达。结果尖锐湿疣组织中Livin和Smac阳性表达率分别为81．03％（47／58）、77．59％（45／58），正常人对照组Livin和Smac阳性表达率分别为25．00％（5／20）、35．00％（7，20）；尖锐湿疣组织中Livin和Smae阳性表达强度多为（＋＋）～（＋＋＋），正常人对照组多在（-）～（＋＋）。两组Livin和Smac阳性表达率及表达强度差异均具有统计学意义（P〈0．05）。尖锐湿疣组织中Livin和Smac表达呈正相关（r=0．373，P〈0．01）。结论尖锐湿疣组织中存在Livin和Smae过表达，Livin和Smac的过表达可能对尖锐湿疣的发生发展有一定作用。

Objective To explore the expressions of Livin and Smac in condyloma acuminatum （CA） tissue and their roles. Methods The expressions of Livin and Smac were analyzed by immunocytochemical staining with streptavidin-peroxidase （SP） in tissue specimens from the lesions of 58 patients with CA and foreskin of 20 normal human controls. Results The detection rates of Livin and Smac were 81.03%（47/58） and 77.59% （45/58） in CA lesions, respectively, compared to 25.00% （5/20） and 35.00% （7/20） in the controls, respectively. The expressions of Livin and Smac varied from positive （＋＋） to strongly positive （＋＋＋） in CA lesions, and from negative （-） to positive （＋＋） in the controls （both P 〈 0.05）. A positive correlation was found between the expression of Livin and Smac in CA lesions （r = 0.373, P 〈 0.01 ）. Conclusion There is an over- expression of Livin and Smac in CA tissue, which may be involved in the occurrence and development of CA.