弱激光促进糖尿病大鼠模型皮肤创伤愈合的实验研究

Study of Low-Level Laser Therapy Facilitates Cutaneous Wound Healing in Diabetic Rats

探讨弱激光对糖尿病大鼠皮肤创伤愈合过程的影响。32只糖尿病大鼠背部皮肤全层创口随机分为4组,分别为:功率密度5、10和15mW/cm^2的630nm半导体激光照射组及空白对照组。弱激光照射能明显加速创面收缩,减轻炎症反应,加快成纤维细胞的增殖和胶原蛋白的合成,促进上皮细胞和毛细血管再生,促进创伤愈合。其中功率密度15mW/cm^2的弱激光治疗组疗效最为明显。实验前后各组大鼠血糖水平均无显著差异。弱激光对糖尿病大鼠皮肤创伤愈合确实存在促进作用,且疗效存在光学参数依赖性。

To investigate the effect of low-level laser therapy on healing of cutaneous excisional wounds in diabetic rats. The dorsal cutaneous exeisional wounds of 32 diabetic rats were divided randomly into 4 groups. Three groups were irradiated with a 630 nm semiconductor laser each with respective three power densities of 5,10 and 15 mW/cm^2, whereas the fourth group served as a eontroh Low-level laser irradiation can obviously accelerate wound contraction,reduce inflammatory reaction significantly, speed fibroblasts proliferation and collagen synthesis, promote epithelial cells and capillaries regeneration, promote wound healing.Effect of low-level laser therapy with 15 mW/cm^2 is most obvious. Before and after the experiment blood glucose levels of all groups were no significant difference. It can be concluded that low-level laser therapy have bene？cial effects on wound healing in diabetic： rats,and the outcomes have a relationship with optical parameters.