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胸腺基质淋巴细胞生成素与变应性皮肤病 被引量：2

Thymic stromal lymphopoietin and allergic dermatoses
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摘要 变心性皮肤病是一类Th2细胞占优势并伴有嗜酸粒细胞浸润和IgE升高为特点的一类疾病，Th1／Th2细胞平衡失调是其重要的发病机制。胸腺基质淋巴细胞生成素是一种IL-7样细胞因子，因为其在变应性皮肤病中的独特作用而引起了众多学者的关注。目前认为其可能在启动Th2驱动的变应怍皮肤病中起总开关和主调节器的作用。概述胸腺基质淋巴细胞生成素及其受体的结构、胸腺基质淋巴细胞生成素如何诱导Th2型细胞反应以及其在变应性皮肤病中的重要作用。 Allergic dermatoses are a group of diseases characterized by Th2 predominance, eosinophilie infiltration and IgE elevation. The imhalance of Th1/Th2 is an important pathogenesis of allergic dermatoses. Thwuic stromal lwnphopoietin （TSLP） ix an inlerleukin 7-like cytokine, and has attracted a lot of attention for its＇distinct roles in allergic dermatoses. Up to now, it has been regarded as a general switch or mater regulator in the triggering of Th12-driven inflammation. Here. the authors review the structure of TSLP and it＇s receptor＇, how TSLP induces Th2 eell responses and the crucial role of ＇ISLP in allergic dermatoses.
作者 王倩 张丽霞
机构地区 四川省医学科学院
出处 《国际皮肤性病学杂志》 2011年第3期161-164,共4页 International Journal of Dermatology and Venereology
关键词 胸腺基质淋巴细胞生成素 皮炎 特应性 变应性 TH2细胞 Thymic stromal lymphopoietin Dermatitis.atopic Allergic Th2 cells
分类号 R758.2 [医药卫生—皮肤病学与性病学]
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参考文献20

  • 1Liu YJ,Soumelis V,Watanabe N,et al.TSLP:an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation.Annu Rev Immunol,2007,25:193-219.
  • 2Sokol CL,Barton GM,Farr AG,et al.A mechanism for the initiation of allergen-induced T helper type 2 responses.Nat Immunol,2008,9(3):310-318.
  • 3Soumelis V,Reche PA,Kanzler H,et al.Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.Nat Immunol,2002,3(7):673-680.
  • 4Oh JW,Seroogy CM,Meyer EH,et al.CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation.J Allergy Clin Immunol,2002,110(3):460-468.
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  • 8Ito T,Wang YH,Duramad O,et al.TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand.J Exp Med,2005,202(9):1213-1223.
  • 9Seshasayee D,Lee WP,Zhou M,et al.In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation.J Clin Invest,2007,117(12):3868-3878.
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同被引文献23

  • 1刘翠杰,刘华昌,孙文杰,罗南萍,高秀芬,靖立美,季建梅,王冬梅.银屑病患者血浆内皮素1测定及其临床意义[J].中华皮肤科杂志,1997,30(2):130-131. 被引量：2
  • 2Zieqler SF,Roan F,Bell BD. The biology of thymic stromal lymphopoietin (TSLP)[J].Advances in pharmacology,2013.129-155.
  • 3Ziegier SF. The role ofthymic stromal lymphopoietin (TSLP) in allergic disorders[J].funr Opin Immunol,2010,(06):795-799.
  • 4Nadir R,Zerimech F,Bouziqon E. The role of eosinophils and basophils in allergic diseases considering genetic findings[J].Current Opinion on Allergy and Clinical Immunology,2013,(05):507-513.
  • 5Friend SL,Hosier S,Nelson A. A thymic stromal cell line supports in vitro development of surface IgM + B cells and produces a novel growth factor affecting B and T lineage cells[J].EXPERIMENTAL HEMATOLOGY,1994,(03):321-328.
  • 6LiuYJ. Thymic stromal lymphopoietin and OX40 ligand pathway in the initiation of dendritic cell-mediated allergic inflammation[J].J Allergy Clin I mmunol,2007,(02):238-244.
  • 7Lee HC,Ziegler SF. Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB[J].Proceedings of the National Academy of Sciences(USA),2007,(03):914-919.
  • 8Bogiatiz SI,Fernandez I,Bichet JC. Cutting edge:proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes[J].Journal of Immunology,2007,(06):3373-3377.
  • 9Calven J,Yudina Y,Hallgren O. Viral stimuli trigger exaggerated thymic stromal lymphopoietin expression by chronic obstructive pulmonary disease epithelium:role of endosomal TLR3 and cytosolic RIG-I-like helicases[J].J Innate Immun,2012,(01):86-99.
  • 10Borowski A,Vetter T,Kuepper M. Expression analysis and specific blockade of the receptor for human thymic stromal lymphopoietin (TSLP) by novel antibodies to the human TSLPRα receptor chain[J].CYTOKINE,2013,(02):546-555.

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国际皮肤性病学杂志
2011年 第3期

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