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造血干细胞分化成肝细胞的可能性

Possibility of differentiation of hematopoietic stem cells into liver cells
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摘要 来自骨髓的造血干细胞具有干细胞的多向分化的潜能.近年来有研究表明,在特定微环境下,造血干细胞能诱导分化成肝细胞,也有研究对此表示争议.本文对造血干细胞是否能有效诱导分化成肝细胞作简要综述. Bone marrow-derived hematopoietic stem cells have the potential to undergo multilineage differentiation.Recent studies have shown that,in a given microenvironment,hematopoietic stem cells can differentiate into liver cells.However,some researchers hold a dissenting view.This review discusses the possibility of differentiation of hematopoietic stem cells into liver cells.
作者 盛瑜 韩国庆
出处 《世界华人消化杂志》 CAS 北大核心 2011年第9期925-929,共5页 World Chinese Journal of Digestology
关键词 造血干细胞 移植 诱导分化 肝细胞 Hematopoietic stem cells Transplantation Differentiation Liver cells
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  • 1Theise ND,Badve S,Saxena R,et al.Derivation of hepatocytes from bone marrow cells in mice after radiation-induced mycloablation.Hepatology,2000,31:235-240.
  • 2Patterson JM,Johnson MH,Zimonjic DB,et al.Characterization of Ly-6M,a novel member of the Ly-6 family of hematopoietic proteins.Blood,2000,95:3125-3132.
  • 3Gupta S,Bhargava KK,Novikoff PM.Mechanisms of cell engraftment during liver repopulation with hepatocyte transplantation.Semin Liver Dis,1999,19:15-26.

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