代谢综合征与中老年人结直肠腺瘤型息肉的关系

Correlation between metabolic syndrome and colorectal adenomatous polyps in middle-and old-aged patients

目的:研究代谢综合征(metabolic syndrome,MS)与中老年人结直肠腺瘤型息肉(colorectal adenoma polyps,CAP)的关系.方法:回顾性分析2007-1/2010-10在中国人民解放军南京军区南京总院干部消化内科住院期间做电子结肠镜检查的45岁以上患者114例的病例资料,根据是否患有CAP分为CAP组(n=64)和对照组(n=50),调查各组患者血糖、血脂、血压、体质量、身高和尿酸情况.根据中华医学会糖尿病分会MS的诊断标准诊断MS,应用单变量和多变量进行统计分析.结果:(1)单因素分析中老年人CAP组MS、高血压、血糖异常和血脂异常患病率明显高于对照组(35.9%vs8.0%;67.2%vs44%;28.1%vs6.0%;48.4%vs30.0%,均P<0.05).虽然两组体质量指数(BMI)患病率无统计学差异,但CAP组BMI患病率有上升的趋势(39%vs24%),两组高尿酸血症患病率无统计学差异;(2)应用多因素逐步Logistic回归分析,MS及血糖异常仍与中老年CAP相关(OR=4.878,4.094;均P<0.05).结论:MS和糖尿病患者是中老年CAP发病高危人群,糖尿病是中老年CAP的独立危险因素.

AIM：To explore the correlation between metabolic syndrome（MS） and colorectal adenomatous polyps（CAP） in middle-and old-aged patients.METHODS：The clinical data for 114 middle-and old-aged patients who were hospitalized at our hospital from January 2007 to October 2010 were retrospectively analyzed.They were divided into two groups：patients with CAP（CAP group,n = 64） and those without CAP（control group,n = 50）.Blood glucose,blood lipids,blood pressure,body mass,height,and blood uric acid were compared between the two groups.MS was diagnosed according to the criteria proposed by the Chinese Diabetes Society.Univariate and multivariate analyses were performed.RESULTS：Patients with CAP had significantly higher rates of MS,high blood pressure,abnormal blood glucose and abnormal blood lipids than controls（35.9% vs 8.0%,67.2% vs 44%,28.1% vs 6.0%,48.4% vs 30.0%,all P 0.05）.Although there was no significant difference in body mass index（BMI） between the two groups,the prevalence of high BMI had a tendency to rise in the CAP group（39% vs 24%,P 0.1）.No significant difference was noted in the prevalence of hyperuricemia between the two groups.CAP was significantly correlated with MS and abnormal blood glucose（OR = 4.878,4.094,both P 0.05）.CONCLUSION：Patients with MS or diabetes are associated with a higher risk of CAP.MS and abnormal blood glucose may be independent risk factors for CAP in middle-and old-aged patients.