蛋白tau表达与乳腺癌紫杉类新辅助化疗敏感性的关系

Correlation between expression of tau and the sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer

目的:探讨原发性乳腺癌组织中tau蛋白的表达与乳腺癌紫杉类药物新辅助化疗敏感性的关系。方法:应用免疫组化法对113例原发性乳腺癌患者术前穿刺样本进行tau蛋白表达水平的检测,分析其与紫杉类药物化疗敏感性的关系。结果:乳腺癌组织中tau蛋白表达的阳性率为24.78%(28/113);紫杉类药物新辅助化疗后,达到病理完全缓解(pCR)的患者40例,存在残留癌的患者73例。pCR组tau蛋白阳性率为12.50%(5/40),残留癌组tau蛋白阳性率为31.51%(23/73),两者之间差异有统计学意义,χ2=5.008,P=0.025。结论:tau蛋白表达水平与乳腺癌紫杉类药物化疗敏感性呈负相关,检测tau蛋白表达状态对预测乳腺癌紫杉类药物新辅助化疗的敏感性可能具有一定的指导意义。

OBJECTIVE： To investigate the correlation of tau protein expression with the sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer.METHODS： The expressions of tau protein in 113 patients with primary breast cancer which were treated with taxane-based neoadjuvant chemotherapy were detected by the immunohistochemical staining,and the results were analysed for the correlation to chemo-sensitivity of taxane.RESULTS： The positive expression rate of tau protein was 24.78%（28/113） in primary breast cancer tissues.After treatment by taxane-based neoadjuvant chemotherapy,40 patients had pathologic complete response（pCR） and 73 patients were residual cancer.The positive expression rates of tau protein were 12.50%（5/40） in pCR group,31.51%（23/73） in residual cancer group,respectibely（χ^2=5.008,P=0.025）.There was a significant difference in the expressions of tau protein between pCR and residual cancer groups.CONCLUSIONS： The tau protein expression is negatively related to the sensitivity of primary breast cancer to taxane.Tau protein expression status may be a useful predictor of sensitivity to taxane-based neoadjuvant chemotherapy in primary breast cancer.