旋毛虫抗肿瘤机制研究进展

Research Progress on Anti-tumor Mechanism of Trichinella spiralis

旋毛虫具有抗多种肿瘤的作用,宿主感染的旋毛虫数量不同,其体内肿瘤受抑制程度亦不同;宿主在感染旋毛虫后的不同时间接种肿瘤细胞,体内肿瘤的生长速度降低程度也不同。旋毛虫在宿主体内发育的不同阶段,均可能具有抗肿瘤作用。旋毛虫通过细胞免疫、肿瘤抗原和抗肿瘤活性物质发挥抗肿瘤作用。

Trichinella spiralis has restrain effect on tumors.Different amount of T.spiralis can emerge different tumor inhibition effect.T.spiralis infection can reduce tumor growth to various extents in mice bearing tumor cells at different times post infection.Each developmental stage of T.spiralis in the host may have anti-tumor effect.T.spiralis may play anti-tumor roles by stimulating cell-mediated immune response,and/or possessing tumor-associated antigen and anti-tumor active substances of the parasite.