虚拟表型方法在HIV-1耐药检测中的应用

Applications of virtual phenotype in HIV-1 resistance detection

艾滋病病毒Ⅰ型(HIV-1)耐药性检测,已成为抗病毒治疗中进行合理用药的重要依据。基因型和表型耐药检测是最常用的HIV耐药检测方法,这两种方法的局限性在于:基因型方法不能直接提供药物耐受信息,表型方法比较耗时。根据上述两种方法之间的良好相关性提出的虚拟表型耐药检测方法,尽管也存在不足,但是提供了另外一种方便的得到耐药信息的方法,从而更好地指导抗病毒治疗。

Detection of resistance mutations is becoming important for the clinical management in antiretroviral therapy（ART）.Genotypic and phenotypic HIV drug resistance tests are generic methods to detect resistance,but the disadvantages are indirect drug resistance information of genotypic test and time consuming of phenotypic test.Although there is deficiency of virtual phenotype,it provides an easy way to get resistance information to guide therapy.