急性脑梗死患者血脂和血浆纤维蛋白原水平的变化及临床意义

Changes and Significance of Blood Lipid and Plasma Fibrinogen Contents in Patients with Acute Cerebral Infarction

目的观察急性脑梗死患者血脂、血浆纤维蛋白原(Fib)水平的变化,探讨其与脑梗死严重程度与预后的相关性。方法分别采用酶比色法、直接法检测56例急性脑梗死患者(ACI组)和45例非急性脑梗死患者(对照组)三酰甘油(TG)、总胆固醇(TCH)和高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,凝血酶比浊法检测Fib水平,并比较ACI组治疗前、后各指标水平的变化。结果 ACI组中TG、TCH、LDL-C、Fib水平明显高于对照组(P均<0.01),HDL-C低于对照组(P<0.05);随着ACI严重程度的增加,TG、TCH、LDL-C和Fib水平逐渐增高,HDL-C水平逐渐降低,ACI轻型组、中型组TG水平与重型组相比,差异均有统计学意义(P<0.05),轻型组TCH、LDL-C、HDL-C水平与重型组相比,差异有统计学意义(P<0.05),轻型组Fib水平与中型组、重型组相比,中型组与重型组相比,差异有统计学意义(P<0.05或<0.01)。结论监测ACI患者血脂、Fib水平的变化,对判断病情、预后及指导治疗有一定的意义。

Objective To explore the changes of blood lipid and plasma fibrinogen contents in patients with acute cerebral infarction,and to investigate the clinical implications of it.Methods Fifty-six hospitalized patients with acute cerebral infarction and forty-five hospitalized patients with no cerebral infarction（control group） were enrolled.The concentrations of triglyceride（TG）,total cholesterol（TCH）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C） and plasma fibrinogen（Fib） were examined for all subjects.The levels of blood lipid and plasma fibrinogen were compared before and after treatment.Results The concentrations of TG,TCH,LDL-C and Fib in hospitalized subjects with acute cerebral infarction before treatment were higher than those in control group（P0.01）;but HDL-C was lower than that in control group meanwhile（P0.05）.With increasing of severity of ACI,the levels of TG,TCH,LDL-C and Fib increased gradually,but HDL-C decreased.There were statistical difference on indexes between each groups before treatment（P0.05 or 0.01）.Conclusion The changes of blood lipid and plasma fibrinogen contents in patients with acute cerebral infarction was helpful in diagnosis,predicting the prognosis and guiding therapy in patients with acute cerebral infarction.