尾加压素Ⅱ与C反应蛋白在妊娠期高血压疾病的作用

Effects of Plasma Urotensin Ⅱ and Serum C-Reactive Protein on Pregnancy-Induced Hypertension Disorder

目的探讨妊娠期高血压疾病孕妇血浆尾加压素Ⅱ(UⅡ)与血清C反应蛋白(CRP)检测水平的临床意义。方法采用酶联免疫吸附法(ELISA)检测30例妊娠期高血压疾病(PIH组)、30例正常孕妇和30例非妊娠健康妇女血浆尾加压素与血清C反应蛋白的水平变化。结果 PIH组血浆尾加压素与血清C反应蛋白检测水平均明显高于正常孕妇和非妊娠健康妇女,差异有统计学意义(P<0.01)。直线相关分析表明PIH组孕妇的血浆尾加压素与血清C反应蛋白具有显著相关性(r=0.893,P<0.01)。结论测定PIH血浆尾加压素与血清C反应蛋白,能够及时了解血管内皮细胞损伤和炎症反应程度,利于本病预防及早期治疗。

Objective To explore the clinical significances of detecting the levels of plasma urotensin Ⅱ（UⅡ） and serum C-reactive protein（CRP） in patients with pregnancy-induced hypertension（PIH） disorder.Methods The levels of plasma UⅡ and CRP of 30 cases with PIH disorder,30 cases normal pregnant women and 30 cases non-pregnant health women were detected by ELISA.Results The levels of plasma UⅡ and serum CRP in patients with PIH were significantly higher than those of other two groups（P0.01）.There was a correlation between UⅡ and CRP in patients with PIH（r=0.893,P0.01）.Conclusion Detection of plasma UⅡ and serum CRP in patients with PIH can confirm the damage of vascular endothelial cell and the degree of inflammation reaction,and play an important role in the prophylaxis and early treatment of this disease.