期刊文献+

2型糖尿病脂代谢紊乱的机制研究进展 被引量:1

Research on mechanisms of lipid metabolism disorder in type 2 diabetes
下载PDF
导出
摘要 糖尿病脂代谢紊乱已经成为心血管疾病独立的危险因素,其主要表现为高甘油三酯血症、低水平的HDL、以及小密度LDL浓度增加。糖尿病脂质代谢紊乱的发生机制尚不清楚.但众多证据表明胰岛素抵抗是其发生的中心环节,近年来的研究还发现肠胰岛素抵抗也参与其中。
作者 徐焱成
出处 《药品评价》 CAS 2011年第9期18-22,共5页 Drug Evaluation
  • 相关文献

参考文献38

  • 1Shafrir E,Raz I.Diabetes:mellitus or lipidus[J].Diabetologia,2003,46:433-440.
  • 2Rana JS,Visser ME,Arsenault BJ,et al.Metabolic dyslipidemia and risk of future coronary heart disease in apparently healthy men and women:The EPIC-Norfolk prospective population study[J].Int J Cardiol doi,2010,143:399-404.
  • 3Mooradian AD.Cardiovascular disease in type 2 diabetes mellitus:current management guidelines[J].Arch Intern Med,2003,163:33-40.
  • 4Chahil TJ and Ginsberg HN.Diabetic dyslipidemia[J].Endocrinol Metab Clin North Am,2006,35:491-510.
  • 5Frayn KN.Adipose tissue and the insulin resistance syndrome[J].Proc Nutr Soc,2001,60:375-380.
  • 6Kashyap S,Belfort R,Berria R,et al.Discordant effects of a chronic physiological increase in plasma FFA on insulin signaling in healthy subjects with or without a family history of type 2 diabetes[J].Am J Physiol Endocrinol Metab,2004,287:E537-E546.
  • 7Gehrmann W,Eisner M,Lenzen S.Role of metabolically generated reactive oxygen species for lipotoxicity in pancreatic β -cells[J].Diabetes Obes Metab,2010,12:149-158.
  • 8Cnop M,Hannaert JC,Grupping AY,et al.Low density lipoprotein can cause death of islet b-cells by its cellular uptake and oxidative modification[J].Endocrinology,2002,143:3449-3453.
  • 9Ai M,Otokozawa S,Schaefer EJ,et al.Glycated albumin and direct low density lipoprotein cholesterol levels in type 2 diabetes mellitus[J].Clinica chimica acta; international journal of clinical chemistry,2009,406(1-2):71-74.
  • 10Azzout-Marniche D,Becard D,Guichard C,et al.Insulin effects on sterol regulatory-element-binding protein-lc(SREBP-lc) transcriptional activity in rat hepatocytes[J].Biochem J,2000,350:389-393.

同被引文献10

引证文献1

二级引证文献4

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部