经静脉注射FX530对实验性兔VX_2肝癌超声造影的研究

Ultrasonographic study of experimental rabbit VX 2 liver carcinomas by intravenous injection of FX530

目的评价经静脉注射新型声学造影剂ＦＸ５３０观察实验性兔ＶＸ２肝癌的效果。方法先制作兔ＶＸ２肝癌模型１５只，共２０个肿瘤结节。经静脉注射ＦＸ５３０后观察兔肝内正常结构和肿瘤的二维灰阶增强情况。结果造影后，兔肝实质、肝内动脉、门静脉和肿瘤血管明显增强，肿瘤组织增强较弱或不增强，肿瘤的可视性增加，并可检出微小的肿瘤结节。结论静脉注射新型声学造影剂提高了超声对肝癌的观察能力。

Objective\ To investigate the efficacy of ultrasonography observing the experimental rabbit VX 2 liver carcinomas by intravenous administration of ultrasonographic contrast agent FX530. Methods\ The animal models of transplanted VX 2 carcinomas in the livers of 15 rabbits (20 nodules) were prepared. After intravenous injection of FX530, grey scale ultrasonography was used to observe the enhancememt of liver textures and VX 2 liver carcinomas. Results\ After injection, grey scale ultrasonography of the liver parenchyma, arteries and portal veins in the liver and the carcinoma vascularities were well enhanced. As the tumor tissue was slightly enhanced or not enhanced, the visibility of the VX 2 carcinomas was greatly improved, even very small carcinomas could be detected.Conclusions\ Intravenous ultrasonographic contrast agent could improve the visualization of hepatic carcinoma.