自固化磷酸钙人工骨的遗传毒理学试验研究

Study on the inherited toxic tests of an artificial bone material made from self-setting calcium phosphate

本文报告了自固化磷酸钙（CPC）人工骨的遗传毒性试验结果。试验采用了3种短期测试试验，项目包括Ames试验、微核试验及UDS试验。结果表明，CPC浸出液对体细胞的遗传物质无损害作用，无致基因突变的作用。由此可见，CPC具有良好的生物相容性，适合于作为体内植入材料。

This paper presented the inherited toxic tests on self-setting calcium phosphate cement (CPC) as an artificial bone material .The tests were done with the use of the extracts by physiological saline, and the items of which included Ames test, microneuclear test and UDS test.The results showed that there was no harmful impact on inherited material, no mutagenesis. The conclusion was made that CPC has a highly biological compatibility and was qualified as an artificial implanting material.