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PEDF和KBP对新生血管抑制作用的研究进展

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摘要 血管增生是指由已存在的微血管床产生新的毛细血管芽的过程,主要是在毛细血管和细静脉的基础上发生发展.这种新生血管对机体的创伤和组织缺血有积极的作用,但对于肿瘤、糖尿病合并症、血管增生性眼病等疾病则是其共同病理特征,因此抑制新生血管增生成为治疗这些疾病的共同点.目前丝氨酸蛋白酶抑制剂已成为内源性血管生成抑制因子研究的热点,本文就丝氨酸蛋白酶抑制剂中色素上皮衍生因子(pigment epithelium-derived factor,PEDF)和激肽释放酶结合蛋白(kallikrein-binding protein,KBP或kallistatin)的研究现状进行综述.
作者 席晓婷 李燕
出处 《国际眼科纵览》 2011年第2期123-127,共5页 International Review of Ophthalmology
基金 云南省科技创新强省国际科技合作计划(2010CA006) 云南省科技厅昆明医学院应用基础研究联合专项(2009CD157)
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