冠菌素生物合成的研究进展

Progress in biosynthesis of coronatine

介绍了冠菌素生物合成的研究进展,总结了冠菌素合成研究的3个阶段。介绍了近年来发酵生产冠菌素菌株的选育及诱变,重点总结了发酵生产冠菌素过程中培养条件优化,指出了目前冠菌素的生物合成仍然存在产量低、发酵条件苛刻等不足,在新菌株的选育、分子手段的应用以及培养基优化是今后生物合成冠菌素研究的热点。

The bacterial strains and fermentation conditions involved in the biosynthesis of coronatine（COR） are reviewed. Three stages about the study of synthesis coronatine are summarized. Mutation breeding of the coronatine strain by fermentation in recent years are introduced. The optimization of fermentation conditions for COR is highlighted. The problems such as low efficiency of biosynthesis, the harsh fermentation conditions, and so on, are pointed out. Research on the new strains, the related genes and enzyme and the optimization of fermentation conditions are suggested for further studies in the future.