三磷酸肌醇清除自由基的作用

采用电子自旋共振波谱仪检测了三磷酸肌醇（IP3）清除羟基自由基（·OH）和超氧阴离子自由基（O）的作用。结果表明：利用Fenton反应体系，酵母和植酸酶制备的IP3对基自由基（·OH）的清除率各达75．34％和73．29％，样品浓度分别为6mg／ml和9mg／ml；利用次黄嘌呤-黄嘌呤氧化酶体系，酵母和植酸酶制备的IP3对超氧阴离子自由基（O）的清除率达72．76％和53．84％，样品浓度分别为18mg／ml和9mg／ml。同时认为IP3之所以对多种疾病具有预防、减轻和治疗效果，主要是因为IP3具有比较强大的清除自由基的功能。

Effecs of inositol triphosphate (IP3)on scavenging free radicals were identified by electron paramagnetic resonance (EPR)spectroscopy.In Fenton reaction system.the scavenging rate of (OH)by IP:(produced by baker's yeast )In 6mg/ml was 75.34%. the scavenging rate of (OH)by IP3(produced by phytase) in 9mg/ml was 73.29%.In HX-OX reaction system .the scavenging rate of(O)by IP3(produced by baker's yeast )in 18mg/ml was 72.76%.the scavenging rate of (O._2) by IP_3(produced by phytase )in 9mg/ml was 53.84％. It was deduced that.thc reason why IP_3 could be used as a curative for preventing alleviating or combating several diseases was that IP_3 could scavenge free radicals efficiently.