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胃蛋白酶原亚群测定与萎缩性胃炎相关性研究及效价比分析 被引量:7

Studies on Relationship of Atrophicgastritis and Pepsinogen Subtypes and Effect-Cost Ratio
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摘要 目的:研究血清中胃蛋白酶原(pepsinogen)亚群(PGⅠ、PGⅡ)含量在健康体检者及胃部疾病患者中的水平,探讨血清中PG亚群测定对萎缩性胃炎及胃癌早期诊断的意义。方法:利用放射免疫法(RIA)测定35例健康体检者、18例胃溃疡患者、30例萎缩性胃炎患者、30例胃癌患者中PGⅠ、PGⅡ及PGⅠ/PGⅡ值的变化,在正常组(健康体检者)与各疾病组之间进行统计学比较,并比较胃蛋白酶原检测与胃镜和(或)病理检查费用的效价比。结果:(1)与正常组相比,消化性溃疡患者PGⅠ、PGⅡ升高,且PGⅡ增高明显,PGⅠ/PGⅡ比值降低;萎缩性胃炎组和胃癌组PGⅠ水平均呈下降趋势,但PGⅡ水平变化不明显,PGⅠ/PGⅡ比值下降。(2)与溃疡组相比,萎缩性胃炎和胃癌患者PGⅠ、PGⅡ及PGⅠ/PGⅡ比值均明显降低。(3)与萎缩性胃炎组相比,胃癌患者PGⅠ、PGⅡ及PGⅠ/PGⅡ比值虽略低于萎缩性胃炎,但差异无统计学意义。(4)PGⅠ≤80ng/mL且PGⅠ/PGⅡ≤6时,检出萎缩性胃炎的特异度和灵敏度分别为94.3%和53.3%。结论:(1)血清PGⅠ和PGⅠ/PGⅡ比值的降低,是萎缩性胃炎及胃癌人群筛查和辅助诊断的一项血清学指标。(2)血清PGⅠ≤80ng/mL且PGⅠ/PGⅡ≤6检测萎缩性胃炎具有较好的特异度和灵敏度。(3)测定血清中PG亚群的方法简单易行,适用于初筛及胃镜检查禁忌者,且与直接行胃镜并取病理检查相比较为经济。 Objective: To study variation of Serum pepsinogen subgroups (pepsinogen, PGⅠ , PG Ⅱ ) content in healthy persons and patients with stomach diseases, and investgate serum pepsinogen subgroups (pepsinogen, PG Ⅰ , PG Ⅱ ) content for significant of early diagnosis of atrophic gastritis and gastric cancer. Methods: The changes of PG Ⅰ , PG Ⅱ and the PG Ⅰ /PG Ⅱ with radioimmunoassay (RIA) were measured in healthy persons, gastric ulcer, chronic atrophic gastritis and gastric cancer patients. The normal control group and every disease group were statistically compared. Results: ( 1 ) Compared with the normal control group, the content of serum PG Ⅰ in atrophic gastritis and gastric cancer patients were decreasing (P 〈0.05), and the ratio of PG Ⅰ / PG Ⅱ was also decreasing, but the content of serum PG Ⅱ did not change significantly. (2) Compared with the peptic ulcer patients, the content of serum PG Ⅰ , PG Ⅱ and the ratio of PG Ⅰ / PG Ⅱin atrophic gastritis and gastric patients cancer decreased significantly (P 〈0.05). (3) Compared with the atrophic gastritis patients, the content of PG Ⅰ, PG Ⅱ and the ratio of PG Ⅰ / PG Ⅱ in gastric cancer patients was slightly lower, but the difference was not statistically significant. (4) When PG I ≤80 ng/mL and the PG Ⅰ /PG Ⅱ -〈6, the sensitivity and specificity for detection of atrophic gastritis are 53.3% and 94.3%.Conclusion: (1) The content of serum PG Ⅰ and the ratio of PG Ⅰ / PG Ⅱ are serum markers for screening and supplementary diagnosis of atrophic gastritis and gastric cancer. (2) The serum PG Ⅰ and PG Ⅰ / PG Ⅱ decreasing are risk factors for atrophic gastritis, which may be as a screening and supplementary diagnosis serum markers in local people. (3). This method is simple and easy to operate and suitable for screening, and save the country's medical resources.
出处 《中国药物经济学》 2011年第1期64-71,共8页 China Journal of Pharmaceutical Economics
关键词 萎缩性胃炎 蛋白酶原亚群 放射免疫分析 效价比 atrophicgastritis Pepsinogen Radioimmunoassay effect-cost ratio
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参考文献16

  • 1Kwong Ming Fock,Nick Talley.Asia-Pacific consensus guidelines on gastric cancer prevention[J].Journal of Gastroenterology and Hepatology,2008,23:351-365.
  • 2Kuninushi Kiyohira,Masaharu Yoshihara.Serum pepsinogen concentration as a marker of Helicobacter pylori infection and the histologic grade of gastritis; evaluation of gastricmucosa by serum pepsinogen levels[J].Journal of gastrocnterol,2003,38:332-338.
  • 3Diana Aulia,Gaby Octavia Manz.Pepsinogen I Concentration in Organic Dyspepsia Patients at Gastroenterology Division[J].Acta Med Indones-Indones J Intern Med,2009,41(3):107-114.
  • 4Kuninushi Kiyohira,,Masaharu Yoshihara.Serum pepsinogen concentration as a marker of Helicobacter pylori infection and the histologic grade of gastritis; evaluation of gastricmucosa by serum pepsinogen levels[J].Journal of gastroenterol,2003,38:332-338.
  • 5Diana Aulia,Gaby Octavia Manz.Pepsinogen I Concentration in Organic Dyspepsia Patients at Gastroenterology Division[J].Acta Med Indones-Indones J Intern Med,2009.41(3):107-114.
  • 6R sierra.Antibodies to Helicobeter Plyori and pepsinogen Levels in children from costa rica:comparison of two areas with different risks for stomach cancer[J].Cancer Epdemiology,1992,(1):149-154.
  • 7Ma rio Dinis-Ribeiro.Validity of Serum Pepsinogen Ⅰ/Ⅱ Ratio for the Diagnosis of Gastric Epithelial Dysplasia and Intestinal Metaplasia during the Follow-Up of Patients at Risk for IntestinalType Gastric Adenocarcinoma[J].Pepsinogen Validity in Intestinal Metaplasia and Gastric Dysplasia,2004,6(5):449-456.
  • 8Jian-Song Ren,Farin Kamangar.Serum pepsinogens and risk of gastric and esophageal cancers[J].Gut,2009,58(5):636--642.
  • 9Miyoko Yamaoka and Shigemi Nakajima.Prevalence of Subjects at a High or Very High Risk of Gastric Cancer in Japan[J].Gut and Liver,2009,3(2):95-100.
  • 10Je woo.kim and ki sup chung.Serum gastrin and pepsinogen Ⅰand Ⅱ concentrations in children with Helicobacter pylori.infection:the role of cagA and vacA.Yonsei MedicalJournal,1998,39(2):159-165.

二级参考文献40

  • 1李哲夫,王德昭,乐竹琴.胃泌素与胃癌[J].国外医学(消化系疾病分册),1993,13(2):69-72. 被引量:11
  • 2Shan-Zhi Gu,Xin-Han Zhao,Ping Quan,Sheng-Bin Li,Bo-Rong Pan.Alterations of serum cholinesterase in patients with gastric cancer[J].World Journal of Gastroenterology,2005,11(29):4604-4606. 被引量:4
  • 3KatherineDCrew,AlfredINeugut.Epidemiology of gastric cancer[J].World Journal of Gastroenterology,2006,12(3):354-362. 被引量:188
  • 4张祥宏,中华消化杂志,1999年,19卷,188页
  • 5张祥宏,中国公共卫生学报,1998年,17卷,246页
  • 6Ferlay J,Bray F,Pisani P,Parkin DM.GLOBOCAN 2000:Cancer Incidence,Mortality and Prevalence Worldwide.Version 1.0.IARC Cancer Base No.5.Lyon:IARC Press,2001.
  • 7Sipponen P,Kekki M,Haapakoski J,Ihamaki T,Siurala M.Gastric cancer risk in chronic atrophic gastritis:statistical calculations of cross-sectional data.Int J Cancer,1985,35:173~177.
  • 8Koga M,Miyakawa K,Ikeda S.Annual Report of Gastroenterological Mass Survey in Japan,2002.Tokyo:Japanese Society of Gastroenterology Mass Survey.2004.
  • 9Sipponen P,Ranta P,Helske T,Kaariainen I,Maki T,Linnala A,Suovaniemi O,Alanko A,Harkonen M.Serum levels of amidated gastrin-17 and pepsinogen Ⅰ in atrophic gastritis:an observational case-control study.Scand J Gastroenterol,2002,37:785~791.
  • 10Sipponen P,Harkonen M,Alanko A,Suovaniemi O.Diagnosis of atrophic gastritis from a serum sample.Clin Lab,2002,48:505~515.

共引文献175

同被引文献50

  • 1中国慢性胃炎共识意见[J].胃肠病学,2006,11(11):674-684. 被引量:835
  • 2张颖,张志广.胃肠道疾病对生长激素释放肽表达的影响[J].医学综述,2007,13(2):125-126. 被引量:4
  • 3Serenella C, Annalisa M, Letizia P, et al. Serum ghrelin as a marker of atrophic body gastritis in patients with parietal cell antibodies[J]. J Clin Endo,2007,92(11) :4346-4351.
  • 4Junichi K, Shino O, Tomoya S, et al. Circulating aeylated ghrelin level decreases in accordance with the extent of atrophic gastritis[J]. J Gastroenterol,2009,44(8) :1046-1054.
  • 5Anna Z,Kazimierz R,Stanislaw JK,et aI. Ghrelin in diseases of the gastrie mueosa associated with Helicobacter pylori infection [J]. Med Sei Monit,2010,16(10):493-500.
  • 6Storskmbb T, Aro P, Ronkainen J, et at. Serum biomarkers provide an aeeurate method for diagnosis of atrophic gastritis in a general population: the Katixanda study[J]. Seand J Gastroenterot,2008,43 (12) : 1448-1455.
  • 7Sehottker B, Adamu MA, Weck MN, et al. Helieobacter pylori infeetion, ehronic atrophic gastritis and major cardiovascular events: a population-based cohort study [J]. Atheroselerosis, 2012,220 (2) :569-574.
  • 8Frank B,Weck MN, MUller H, et al. Polymorphisms in MUC1, MUC2, MUCSB and MUC6 genes are not associated with the risk of chronic atrophic gastritis [ J]. Eur J Cancer,2012,48 (1) :114- 120.
  • 9Vanoli A, La Rosa S, Luinetti O, et al. Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: the predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions [ J ]. Hum Patho1,2013,44 ( 9 ) : 1827-1837.
  • 10Pomytkina TE.The serum content of gastrin-17 and pepsinogen-1 in pa-tients with duodenal ulcerative disease in occupational contact with ni-trogenous compounds[].Klinicheskaia Laboratornaia Diagnostika.2009

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