内蒙古自治区中西部地区妇女宫颈人乳头瘤病毒感染现状调查及分析

The investigation and analysis of present situation of human papilloma virus infection of women cervixes in parts of Inner Mongolia Autonomous Region

目的了解内蒙古中西部地区妇女宫颈人乳头瘤病毒（HPV）感染的分布情况及高危因素,为该地区宫颈癌防治及流行病学研究提供一定的依据。方法采用导流杂交技术对4188例有性生活妇女宫颈脱落细胞进行21种HPV基因型检测,分析HPV感染高危因素及宫颈病变中HPV亚型感染分布特点。结果在被调查的4188例妇女中HPV感染总阳性率为23.3%（975/4188）,所有21种HPV亚型被检测出来。HPV感染阳性排在前5位的亚型从高到低依次为HPVl6、58、52、33和l8,感染率从高到低分别为：16亚型,占28.5%;58亚型,占9.1%;52亚型,占6.2%;33亚型,占4.8%;18亚型,占4.7%;最低为51亚型,占0.5%。HPV感染的高峰年龄为36~40岁,各年龄段HPV感染检出率差异在统计学上有显著性意义（P〈0.01）。61岁以上年龄组阳性检出率最高,为33.3%。结论内蒙古自治区HPV亚型感染分布以l6、58、52、33型为主,且存在明显的地域差异,在本地区所有21种HPV亚型都被检测出来。HPV感染高发于中青年妇女。

Objective To investigate the distribution of different human papillomavirus（HPV） subtypes infection of women cervixes in parts of Inner Mongolia Autonomous Region and the high risk factors of HPV infection, in order to offer evidences for the epidemiology of HPV and prevention of cervical cancer in the region. Methods A total of 4188 women having sexual life were checked for 21 HPV genotypes by DNA flowthrough hybridization technique. The high risk factors of HPV infection and the distribution feature of HPV subtypes infection in the different cervical diseases were analyzed. Results The total positive rate of HPV infection is 23.3%（975/4188）. There were 21 HPV subtypes having been detected. HPV subtypes infection from high to low were HPV l6, 58, 52, 33 and l8. The rates of HPV subtypes infection were 28.5%, 9.1%, 6.2%, 4.8%, 4.7%, respectively; The lowest was 51 subtype, 0.5%. The peak age of HPV infection ranged from 36 to 40 years old. There was significant difference between different aged groups（P0.01）. Conclusion The major HPV subtypes are l6, 58, 52, 33 and l8 in Inner Mongolia Autonomous Region. HPV infection rate and distribution vary in some extent in different regions.