摘要
目的:探讨固本益肾胶囊对急性血瘀症模型大、小鼠的血液流变学指标的影响。方法:50只大鼠,随机分为正常对照组,血瘀症模型组,血府逐瘀胶囊组(1.2 g·kg-1),固本益肾胶囊高剂量组(2.25 g·kg-1)、固本益肾胶囊低剂量组(0.75 g·kg-1)。采用sc 0.1%肾上腺素,之后进行寒冷刺激造成急性血瘀症模型,分别测定各组大鼠高、中、低切变率(230,11.50s-1)下的全血黏度,血浆黏度、血清黏度、纤维蛋白原黏度、全血还原黏度、红细胞压积、血小板聚集电阻值及小鼠凝血时间。结果:固本益肾胶囊2.25,0.75 g·kg-12个剂量组能明显降低高、中、低切变率下的全血黏度,降低血浆黏度及纤维蛋白原黏度,降低高、低切变率下的全血还原黏度、降低红细胞压积,减少血小板聚集电阻值,延长小鼠凝血时间(P<0.05或P<0.01)。结论:固本益肾胶囊可明显改善急性血瘀症模型动物的血液流变性。
Objective：To explore the effect of Guben Yishen Capsule（GB-C）on the hemorheological parameters for acute blood stasis in rats and mice.Method：The model of blood stasis in rats was prepared by injection of 0.1% epinephrine and putting them into ice-water for several minutes.The model of stasis in mice was established in the similar manner.The whole blood viscosities at low,middleand high shear rates,plasma viscosity,serum viscosity,fibrinogen viscosity,whole blood reduction viscosity,hematocrit,platelet aggregation resistance index and the clotting-time of mice were measured.Result：GB-C at 2.25,0.75 g·kg-1 doses could markedly decrease the whole blood viscosities at low,middle and high shear rates,plasma viscosity,fibrinogen viscosity,and whole blood reduction viscosities at low,high shear rates and hematocrit were decreased,decrease platelet aggregation resistance index,and the clotting-time of mice was extended（P0.05,P0.01）.Conclusion：GB-C can ameliorate the indexes in hemorheology in animals with acute blood stasis.
出处
《中国实验方剂学杂志》
CAS
北大核心
2011年第10期169-172,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
庆阳市科技局项目(0902NKCM065)
