增液解毒颗粒干预放射性肺损伤

Prevention Effect of Zengye Jiedu Granule on Radiation-induced Pulmonary Injury

目的:探讨增液解毒颗粒在放射性肺损伤的预防作用。方法:将肺癌、食管癌患者共60例作为本研究的切入点。设立中药加放疗组(实验组)和单纯放疗组(对照组),每组各30例,2组均行三维适形放疗,实验组同时给予增液解毒颗粒口服。记录住院期间2组放射性肺损伤发生情况。结果:实验组放射性肺损伤的发生率26.67%,3～4级发生率6.67%、平均发病时间31 d,均优于对照组(P<0.05)。结论:增液解毒颗粒能有效防治严重性急性放射性肺损伤的发生,推迟放射性肺损伤发生时间,对减轻放射性肺损伤、提高生存质量、保证放疗的顺利进行具有积极意义。

Objective：To investigate the prevention effect of Zengye Jiedu granule on radiation-induced pulmonary injury.Method： Sixty patients with lung cancer or esophagus cancer were divided into two groups,30 cases were treated only by the radiotherapy（control group）,another 30 cases were treated by radiotherapy and＇Zengye Jiedu granule＇（treatment group）.Radiation-induced pulmonary injury was observed.Result： The total incidence rates of acute radiation pneumonitis in the treatment group and the control group were 26.67% and 33.33% respectively.Grade 3 or 4 acute radiation pneumonitis occurred in 6.67% of patients treated with Zengyejiedu granule,and 26.67% in the control group.The average onset time of acute radiation pneumonitis occurred was 31days and 37 days respectively.Conclusion： Zengye Jiedu granule is effective in preventing the occurrence of Grade 3 or 4 acute radiation pneumonitis and delaying the occurrence of radiation-induced pulmonary injury.It is proved that Zengye Jiedu granule may elevate the quality of life and ensure successful radiotherapy.