丁二磺酸腺苷蛋氨酸在化疗药物所致肝功能损害中的作用

The effect of ademetionine 1,4-butanedisulfonate on liver injury induced by chemotherapeutic agents

目的:观察丁二磺酸腺苷蛋氨酸治疗化疗药物引起的药物性肝损伤的疗效。方法:将60例血液病化疗患者随机分为两组,各30例,试验组化疗期间应用丁二磺酸腺苷蛋氨酸,对照组则应用其他常规保肝药物进行预防治疗,观察两组患者治疗前后丙氨酸氨基转移酶和天冬氨酸氨基转移酶及胆红素变化。结果:试验组转氨酶和胆红素的有效率分别为90.00%和93.33%,对照组转氨酶和胆红素的有效率分别为66.67%和60.00%,试验组与对照组疗效比较差异均有统计学意义(均P<0.05)。结论:丁二磺酸腺苷蛋氨酸在治疗化疗药物引起的药物性肝损伤中效果优于其他常规保肝药物。

Objective：To observe the effect of ademetionine 1,4-butanedisulfonate on liver injury induced by chemotherapeutic agents.Methods：60 patients of blood diseases with chemotherapy were randomly divided into experimental group（n=30） and control group（n=30）.The patients in the experimental group were given ademetionine 1,4-butanedisulfonate during the chemotherapy,and the patients in the control group received the other conventional protect liver drugs in prevention and treatment.The changes of ALT,AST and Bilirubin were observed before and after treatment in all patients.Results：The efficient rate of the experimental group with transaminase and Bilirubin were 90.00% and 93.33%,respectively,while the efficient rate of the control group with transaminase and Bilirubin were 66.67% and 60.00%,respectively,there were significant differences between the two groups（P0.05）.Conclusion：The effect of ademetionine 1,4-butanedisulfonate on drug-induced liver injury is better than other conventional liver drugs.