摘要
目的：探讨血管紧张素Ⅱ受体阻滞剂（ARB）替米沙坦联合拜阿司匹灵治疗2型糖尿病早期肾病（DN）对微量白蛋白尿临床治疗效果。方法：将68例临床确诊2型糖尿病（T2DM）早期肾病的患者随机分成治疗组34例和对照组34例，两组的基本治疗是控制饮食和门冬胰岛素30皮下注射控制血糖。对照组在基本治疗的基础上应用替米沙坦和维生素B1，治疗组在基本治疗的基础上联合应用替米沙坦和拜阿司匹灵，疗程均为3月。观察治疗前后两组患者24小时尿微量白蛋白排泄（UAE），血肌酐（SCr）尿素氮（BUN）的变化。结果：两组患者治疗前后自身对比，24小时UAE均有显著性下降（P〈0．05）；与对照组相比，治疗组UAE下降更为明显（P〈0．05）。治疗前后血肌酐及BUN均无明显的变化（P〉0．05）。结论：ARB能降低24小时尿微量白蛋白排泄；在ARB治疗基础上加用拜阿司匹灵，降低24小时尿微量白蛋白排泄方面疗效优于前者。
Objective To investigate the elects of telmisartan combined with bayaspirin on patients with microalbuminuriad early diabetic nephropathy. Methods Sixty--eight patients with mlcroalbuminnria of early diabetic nephropathy were divided randomly into treated group,（n= 34） that were treated with bayaspirin combined with telmisartanor control group（n=34）that Were treated with benazeprll only for three months,based on the same basic diet control and insulin. UAE, SCr and BUN oftwo groups were surveyed before and after treatment. Result After 3 month treatment, the 24h microalbuminuria decreased significantly in both groups（P〈0.05）, but more significantly in the treated group（P〈0.05）, no significant change of the serum creatinine and urea nitrogen was found in both groups（P〉0.05）. Conclusion The combination of telmisartan and bayaspirin is mole elective than telmisartan alone.
