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microRNA及其作用靶点在肿瘤研究和治疗中的作用

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摘要 MicroRNAs通过阻抑翻译或降解RNA来调节靶基因，包括肿瘤相关基因的表达，在肿瘤发生过程中起到重要的作用。探索基于mieroRNA的肿瘤治疗方法是当前世界领域的研究热点。本文就miRNA对肿瘤相关基因表达的影响厦其机制的研究进展作简要综述。 MicroRNAs （miRNAs） regulate expression of target gene, including tumor--related genes, through translation repression or mRNA degradation. Exploring new methods based on microRNA for cancer therapy is one of the hot research fields in world. In this paper, the effects of miRNA on expression of tumor--related genes and underlying mechanism were briefly summarized.
作者 吴红艳 王艳林
机构地区 湖北宜昌三峡大学医学院三峡大学分子生物学研究所
出处 《医学信息（下旬刊）》 2011年第2期341-341,343,共2页 Medical information
关键词 肿瘤 MICRORNA 靶基因 cancer microRNA target gene
分类号 R730 [医药卫生—肿瘤]
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参考文献19

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医学信息（下旬刊）
2011年 第2期

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