HCOONH_4-Pd/C催化转移氢化4-硝基-N-氧吡啶制备4-氨基吡啶

Synthesis of 4Aminopyridine by Catalytic Transferhydrogenation Method

以Ｐｄ／Ｃ为催化剂，甲酸铵为氢给予体，９５％（ｗ）乙醇为溶剂，４硝基Ｎ氧吡啶为原料，在常压下转移氢化合成了４氨基吡啶，收率为９０％。氢化条件温和，后处理简单。用熔点、ＧＣ－ＭＳ谱图表征了该化合物。通过ＧＣ－ＭＳ对反应跟踪分析，发现反应首先生成脱氧化合物４硝基吡啶，继而经过偶氮中间物生成４氨基吡啶，各物质质谱图中碎片峰与理论推导结果一致，证明了该反应历程。

The title compound was obtained from 4aminopyridine1oxide by catalytic transferhydrogenation reduction in the presence of HCOONH4Pd/C at atmospheric pressure in 90% yield.The compound was characterized by melting point,GC-MS spectrometry.The reaction condition is mild,without environmental pollution.